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鸭肠炎病毒 pUL47 作为一种晚期核定位结构蛋白，主要依赖于残基 40 到 50 和 768 到 777 并通过与 STAT1 相互作用抑制 IFN-β 信号转导。

Duck enteritis virus pUL47, as a late structural protein localized in the nucleus, mainly depends on residues 40 to 50 and 768 to 777 and inhibits IFN-β signalling by interacting with STAT1.

机构信息

Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, Sichuan, People's Republic of China.

Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, Sichuan, People's Republic of China.

出版信息

Vet Res. 2020 Nov 11;51(1):135. doi: 10.1186/s13567-020-00859-w.

DOI:10.1186/s13567-020-00859-w
PMID:33176874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7656727/
Abstract

Duck enteritis virus (DEV) is a member of the Alphaherpesvirinae subfamily. The characteristics of some DEV genes have been reported. However, information regarding the DEV UL47 gene is limited. In this study, we identified the DEV UL47 gene encoding a late structural protein located in the nucleus of infected cells. We further found that two domains of DEV pUL47, amino acids (aa) 40 to 50 and 768 to 777, could function as nuclear localization sequence (NLS) to guide the nuclear localization of pUL47 and nuclear translocation of heterologous proteins, including enhanced green fluorescent protein (EGFP) and beta-galactosidase (β-Gal). Moreover, pUL47 significantly inhibited polyriboinosinic:polyribocytidylic acid [poly(I:C)]-induced interferon beta (IFN-β) production and downregulated interferon-stimulated gene (ISG) expression, such as Mx and oligoadenylate synthetase-like (OASL), by interacting with signal transducer and activator of transcription-1 (STAT1).

摘要

鸭肠炎病毒（DEV）是α疱疹病毒亚科的一员。已经报道了一些 DEV 基因的特征。然而，关于 DEV UL47 基因的信息有限。在这项研究中，我们鉴定了 DEV UL47 基因，该基因编码一种位于感染细胞核内的晚期结构蛋白。我们进一步发现，DEV pUL47 的两个结构域，即氨基酸（aa）40 至 50 和 768 至 777，可作为核定位序列（NLS），引导 pUL47 的核定位和异源蛋白的核转位，包括增强型绿色荧光蛋白（EGFP）和β-半乳糖苷酶（β-Gal）。此外，pUL47 通过与信号转导和转录激活因子 1（STAT1）相互作用，显著抑制聚肌苷酸：聚胞苷酸[poly（I：C）]诱导的干扰素β（IFN-β）产生，并下调干扰素刺激基因（ISG）的表达，如 Mx 和寡聚腺苷酸合成酶样（OASL）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/071fb70dbced/13567_2020_859_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/d619e67355ab/13567_2020_859_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/e7046455f157/13567_2020_859_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/09758f9c5b55/13567_2020_859_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/b18f56472515/13567_2020_859_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/1f37367f7c6b/13567_2020_859_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/1c5ec4dd28d5/13567_2020_859_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/978e72319431/13567_2020_859_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/071fb70dbced/13567_2020_859_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/d619e67355ab/13567_2020_859_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/e7046455f157/13567_2020_859_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/09758f9c5b55/13567_2020_859_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/b18f56472515/13567_2020_859_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/1f37367f7c6b/13567_2020_859_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/1c5ec4dd28d5/13567_2020_859_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/978e72319431/13567_2020_859_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3824/7656727/071fb70dbced/13567_2020_859_Fig8_HTML.jpg

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