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两亲性磁性聚乙烯醇靶向药物载体的制备及药物递送研究

Preparation of amphiphilic magnetic polyvinyl alcohol targeted drug carrier and drug delivery research.

作者信息

Wang Yazhen, Shi Zhen, Sun Yu, Wu Xueying, Li Shuang, Dong Shaobo, Lan Tianyu

机构信息

College of Materials Science and Engineering, Qiqihar University, Qiqihar, China.

Heilongjiang Provincial Key Laboratory of Polymeric Composite Materials, Qiqihar, China.

出版信息

Des Monomers Polym. 2020 Oct 23;23(1):197-206. doi: 10.1080/15685551.2020.1837442.

DOI:10.1080/15685551.2020.1837442
PMID:33177950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7594732/
Abstract

Currently, magnetic applications have great potential for development in the field of drug carriers. In this paper, FeO-PVA@SH, an amphiphilic magnetically targeting drug carrier, was prepared by using FeO and PVA with thiohydrazide-iminopropyltriethoxysilane(TIPTS). The loading capacity of FeO-PVA@SH on Aspirin and the drug release kinetics of loaded drugs were studied. The obtained FeO-PVA@SH exhibits excellent drug release properties in simulating the human body fluid environment (pH 7.2). Since magnetically targeting drug carriers are readily available and have excellent biocompatibility and the characteristics of drug release. This work's development, preparing amphiphilic magnetically targeting drug carriers in drug delivery and other fields, has great significance.

摘要

目前，磁性应用在药物载体领域具有巨大的发展潜力。本文采用FeO和聚乙烯醇（PVA）与硫酰肼-亚氨基丙基三乙氧基硅烷（TIPTS）制备了一种两亲性磁性靶向药物载体FeO-PVA@SH。研究了FeO-PVA@SH对阿司匹林的负载能力以及负载药物的释放动力学。所制备的FeO-PVA@SH在模拟人体体液环境（pH 7.2）中表现出优异的药物释放性能。由于磁性靶向药物载体易于获得，具有优异的生物相容性和药物释放特性。这项工作在药物递送等领域制备两亲性磁性靶向药物载体的发展具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/15f41e980a7c/TDMP_A_1837442_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/792bfd908a25/TDMP_A_1837442_SCH0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/bb4642fa3367/TDMP_A_1837442_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/322b0c4a5933/TDMP_A_1837442_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/d342d7644d18/TDMP_A_1837442_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/14aeacb3febe/TDMP_A_1837442_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/a76fbc346ca6/TDMP_A_1837442_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/675084b097e0/TDMP_A_1837442_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/15f41e980a7c/TDMP_A_1837442_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/792bfd908a25/TDMP_A_1837442_SCH0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/bb4642fa3367/TDMP_A_1837442_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/322b0c4a5933/TDMP_A_1837442_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/d342d7644d18/TDMP_A_1837442_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/14aeacb3febe/TDMP_A_1837442_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/a76fbc346ca6/TDMP_A_1837442_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/675084b097e0/TDMP_A_1837442_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d864/7594732/15f41e980a7c/TDMP_A_1837442_F0007_OC.jpg

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2
Biodegradable pH-responsive hydrogels for controlled dual-drug release.用于可控双药释放的可生物降解pH响应水凝胶。
J Mater Chem B. 2018 Jan 21;6(3):510-517. doi: 10.1039/c7tb01851g. Epub 2018 Jan 5.
3
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Expert Opin Drug Deliv. 2020 Jan;17(1):23-32. doi: 10.1080/17425247.2020.1698544. Epub 2019 Dec 3.
4
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5
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