Herrero Carolina, Abal Miguel, Muinelo-Romay Laura
Translational Medical Oncology Group (Oncomet), Health Research Institute of Santiago de Compostela (IDIS), University Hospital of Santiago de Compostela (SERGAS), Santiago de Compostela, Spain.
Nasasbiotech, S.L., A Coruña, Spain.
Front Oncol. 2020 Oct 14;10:565666. doi: 10.3389/fonc.2020.565666. eCollection 2020.
Although liquid biopsy can be considered a reality for the clinical management of some cancers, such as lung or colorectal cancer, it remains a promising field in gynecological tumors. In particular, circulating extracellular vesicles (cEVs) secreted by tumor cells represent a scarcely explored type of liquid biopsy in gynecological tumors. Importantly, these vesicles are responsible for key steps in tumor development and dissemination and are recognized as major players in cell-to-cell communication between the tumor and the microenvironment. However, limited work has been reported about the biologic effects and clinical value of EVs in gynecological tumors. Therefore, here we review the promising but already relatively limited data on the role of circulating EVs in promoting gynecological tumor spread and also their value as non-invasive biomarkers to improve the management of these type of tumors.
尽管液体活检对于某些癌症（如肺癌或结直肠癌）的临床管理而言已成为现实，但在妇科肿瘤领域它仍是一个充满前景的领域。特别是，肿瘤细胞分泌的循环细胞外囊泡（cEVs）在妇科肿瘤中是一种尚未得到充分探索的液体活检类型。重要的是，这些囊泡在肿瘤发展和扩散的关键步骤中发挥作用，并被认为是肿瘤与微环境之间细胞间通讯的主要参与者。然而，关于细胞外囊泡在妇科肿瘤中的生物学效应和临床价值的报道有限。因此，在此我们综述了关于循环细胞外囊泡在促进妇科肿瘤扩散中的作用以及它们作为非侵入性生物标志物以改善这类肿瘤管理的价值的虽有前景但已相对有限的数据。
