Gharbi Tahereh, Zhang Zhijun, Yang Guo-Yuan
Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Front Cell Dev Biol. 2020 Oct 15;8:568889. doi: 10.3389/fcell.2020.568889. eCollection 2020.
Astrocyte activation plays an important role during disease-induced inflammatory response in the brain. Exosomes in the brain could be released from bone marrow (BM)-derived stem cells, neuro stem cells (NSC), mesenchymal stem cells (MSC), etc. We summarized that exosomes release and transport signaling to the target cells, and then produce function. Furthermore, we discussed the pathological interactions between astrocytes and other brain cells, which are related to brain diseases such as stroke, Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) disease, multiple sclerosis (MS), psychiatric, traumatic brain injury (TBI), etc. We provide up-to-date, comprehensive and valuable information on the involvement of exosomes in brain diseases, which is beneficial for basic researchers and clinical physicians.
星形胶质细胞激活在疾病诱导的脑部炎症反应中起重要作用。脑内的外泌体可由骨髓来源的干细胞、神经干细胞、间充质干细胞等释放。我们总结了外泌体释放并向靶细胞传递信号，然后发挥功能。此外，我们讨论了星形胶质细胞与其他脑细胞之间的病理相互作用，这些相互作用与中风、阿尔茨海默病（AD）、帕金森病（PD）、肌萎缩侧索硬化症（ALS）、多发性硬化症（MS）、精神疾病、创伤性脑损伤（TBI）等脑部疾病有关。我们提供了关于外泌体参与脑部疾病的最新、全面且有价值的信息，这对基础研究人员和临床医生都有益处。
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