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基于 CT 图像的肝癌检测与分类的集成方法。

Ensembled liver cancer detection and classification using CT images.

机构信息

Department of Electrical and Instrumentation Engineering, Thapar Institute of Engineering and Technology, Patiala, India.

出版信息

Proc Inst Mech Eng H. 2021 Feb;235(2):232-244. doi: 10.1177/0954411920971888. Epub 2020 Nov 13.

DOI:10.1177/0954411920971888
PMID:33183141
Abstract

Computed tomography (CT) images are commonly used to diagnose liver disease. It is sometimes very difficult to comment on the type, category and level of the tumor, even for experienced radiologists, directly from the CT image, due to the varying intensities. In recent years, it has been important to design and develop computer-assisted imaging techniques to help doctors/physicians improve their diagnosis. The proposed work is to detect the presence of a tumor region in the liver and classify the different stages of the tumor from CT images. CT images of the liver have been classified between normal and tumor classes. In addition, CT images of the tumor have been classified between Hepato Cellular Carcinoma (HCC) and Metastases (MET). The performance of six different classifiers was evaluated on different parameters. The accuracy achieved for different classifiers varies between 98.39% and 100% for tumor identification and between 76.38% and 87.01% for tumor classification. To further, improve performance, a multi-level ensemble model is developed to detect a tumor (liver cancer) and to classify between HCC and MET using features extracted from CT images. The k-fold cross-validation (CV) is also used to justify the robustness of the classifiers. Compared to the individual classifier, the multi-level ensemble model achieved high accuracy in both the detection and classification of different tumors. This study demonstrates automated tumor characterization based on liver CT images and will assist the radiologist in detecting and classifying different types of tumors at a very early stage.

摘要

计算机断层扫描(CT)图像通常用于诊断肝脏疾病。由于强度的不同,即使是经验丰富的放射科医生,也很难直接从 CT 图像上对肿瘤的类型、类别和级别进行评论。近年来,设计和开发计算机辅助成像技术以帮助医生提高诊断水平变得非常重要。本研究旨在从 CT 图像中检测肝脏肿瘤区域的存在,并对肿瘤的不同阶段进行分类。已经对肝脏的 CT 图像进行了正常和肿瘤类别的分类。此外,还对肿瘤的 CT 图像进行了肝细胞癌(HCC)和转移(MET)之间的分类。在不同的参数上评估了六种不同分类器的性能。不同分类器的准确率在肿瘤识别方面在 98.39%到 100%之间变化,在肿瘤分类方面在 76.38%到 87.01%之间变化。为了进一步提高性能,使用从 CT 图像中提取的特征开发了一个多级集成模型来检测肿瘤(肝癌)并对 HCC 和 MET 进行分类。还使用 k 折交叉验证(CV)来验证分类器的稳健性。与单个分类器相比,多级集成模型在不同肿瘤的检测和分类中都实现了很高的准确率。本研究基于肝脏 CT 图像实现了自动肿瘤特征描述,将有助于放射科医生在早期发现和分类不同类型的肿瘤。

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