Controlled evaluation of nabumetone in the treatment of active adult rheumatoid arthritis. Nabumetone versus naproxen double-blind parallel study.

作者信息

Vasey F B, Germain B F, Espinoza L R, Box P, Bockow B I, Lipani J A, Mullen B J, Brodsky A L, Fleischmann R M, Fogari R A

机构信息

Department of Internal Medicine, University of South Florida College of Medicine, Tampa 33612.

出版信息

Am J Med. 1987 Oct 30;83(4B):55-9. doi: 10.1016/0002-9343(87)90595-x.

Nabumetone is a new nonsteroidal anti-inflammatory agent. Therapy with nabumetone 1,000 mg given at bedtime was compared with naproxen 250 mg given twice daily in a prospective double-blind study of patients with rheumatoid arthritis. Both drugs were found to be efficacious in a comparable fashion. Both drugs were well tolerated in terms of patient withdrawal rates, which were 5 and 8 percent, respectively. Gastrointestinal side effects were the most commonly encountered problem. Nabumetone holds promise as an important new therapeutic approach in arthritis.