Zárate Ignacio A, Aguilar-Bolados Héctor, Yazdani-Pedram Mehrdad, Pizarro Guadalupe Del C, Neira-Carrillo Andrónico
Departamento de Ciencias Biológicas, Facultad de Ciencias Veterinarias y Pecuarias, Universidad de Chile, Av. Sta. Rosa, La Pintana, 11735 Santiago, Chile.
Departamento de Química Orgánica y Físico Química, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Olivos, Independencia, 1007 Santiago, Chile.
Polymers (Basel). 2020 Nov 11;12(11):2663. doi: 10.3390/polym12112663.
Electrospun meshes (EM) composed of natural and synthetic polymers with randomly or aligned fibers orientations containing 0.5% or 1% of thermally reduced graphene oxide (TrGO) were prepared by electrospinning (ES), and their hyperthermia properties were evaluated. EM loaded with and without TrGO were irradiated using near infrared radiation (NIR) at 808 nm by varying the distance and electric potential recorded at 30 s. Morphological, spectroscopic, and thermal aspects of EM samples were analyzed by using SEM-EDS, Raman and X-ray photoelectron (XPS) spectroscopies, X-ray diffraction (XRD), and NIR radiation response. We found that the composite EM made of polyvinyl alcohol (PVA), natural rubber (NR), and arabic gum (AG) containing TrGO showed improved hyperthermia properties compared to EM without TrGO, reaching an average temperature range of 42-52 °C. We also found that the distribution of TrGO in the EM depends on the orientation of the fibers. These results allow infering that EM loaded with TrGO as a NIR-active thermal inducer could be an excellent candidate for hyperthermia applications in photothermal therapy.
通过静电纺丝（ES）制备了由天然和合成聚合物组成、纤维取向随机或排列且含有0.5%或1%热还原氧化石墨烯（TrGO）的静电纺丝网（EM），并对其热疗性能进行了评估。通过改变距离并在30秒时记录电势，使用808nm的近红外辐射（NIR）对负载和未负载TrGO的EM进行照射。通过扫描电子显微镜-能谱仪（SEM-EDS）、拉曼光谱和X射线光电子能谱（XPS）、X射线衍射（XRD）以及近红外辐射响应来分析EM样品的形态、光谱和热学方面。我们发现，与不含TrGO的EM相比，由聚乙烯醇（PVA）、天然橡胶（NR）和阿拉伯胶（AG）组成且含有TrGO的复合EM表现出更好的热疗性能，平均温度范围达到42-52°C。我们还发现，TrGO在EM中的分布取决于纤维的取向。这些结果表明，负载TrGO作为近红外活性热诱导剂的EM可能是光热疗法中热疗应用的极佳候选材料。
