Postgraduate Program in Nutrition, Universidade Federal de Santa Catarina, Florianopolis, Brazil.
Department of Collective Health, Universidade Federal do Maranhão, Maranhão, Brazil.
Public Health Nutr. 2022 Sep;25(9):2507-2516. doi: 10.1017/S1368980021004407. Epub 2021 Oct 25.
To investigate the association between serum vitamin D (25-hydroxy-cholecalciferol) (25(OH)D) concentrations and cognitive impairment in older adults living in Southern Brazil.
Cross-sectional analysis using data from the second follow-up wave of the populational-based EpiFloripa Aging Cohort Study was collected in 2013-2014.
Cognitive impairment was evaluated using the Mini-Mental State Examination (MMSE). Blood samples were collected to measure serum vitamin D concentrations using a chemiluminescent microparticle immunoassay. Vitamin D concentrations were distributed in quartiles (Q1: 4·0-20·7 ng/ml; Q2: 20·8-26·6 ng/ml; Q3: 26·7-32·0 ng/ml and Q4: 32·1-60·1 ng/ml), and its association with cognitive impairment was tested by crude and adjusted logistic regression (sociodemographic, behavioural and health aspects) using Q4 as a reference group.
200 men and 371 women aged 60 years or older participated in this study.
The prevalence of probable cognitive impairment was 21·7 %. Those without cognitive impairment had a higher mean of vitamin D serum concentrations (26·8 . 24·6, = 0·014). In the crude analysis, only individuals in Q2 of vitamin D presented an increased risk for probable cognitive impairment compared with Q4 (highest quartile) (OR 2·65, 95 % CI 1·46, 4·81), remaining significant in the adjusted analysis (OR 6·04, 95 % CI 2·78, 13·13). While Q1 (lowest quartile) was not associated in the crude analysis, but when adjusted, an increased risk of cognitive impairment was observed.
The lowest quartile of vitamin D was directly associated with probable cognitive impairment in older adults in Southern Brazil. More studies are needed to investigate whether maintaining adequate serum levels may represent a significant factor in preventing age-related neurological disorders as well as to verify the need for new cutoff points for this age group.
研究巴西南部老年人血清维生素 D（25-羟胆钙化醇）（25（OH）D）浓度与认知障碍的关系。
使用 2013-2014 年基于人群的 EpiFloripa 老龄化队列研究第二随访波的数据进行横断面分析。
使用简易精神状态检查（MMSE）评估认知障碍。采集血样，使用化学发光微粒子免疫测定法测量血清维生素 D 浓度。将维生素 D 浓度分布在四分位数（Q1：4·0-20·7ng/ml；Q2：20·8-26·6ng/ml；Q3：26·7-32·0ng/ml和 Q4：32·1-60·1ng/ml），并使用 Q4 作为参考组，通过非条件和调整后的逻辑回归（社会人口统计学、行为和健康方面）测试其与认知障碍的关系。
200 名男性和 371 名 60 岁或以上的女性参加了这项研究。
可能的认知障碍患病率为 21.7%。没有认知障碍的人维生素 D 血清浓度较高（26·8±24·6， = 0·014）。在粗分析中，与 Q4（最高四分位数）相比，仅 Q2 组的维生素 D 个体发生可能的认知障碍的风险增加（OR 2.65，95%CI 1.46，4.81），在调整分析中仍然显著（OR 6.04，95%CI 2.78，13.13）。虽然 Q1（最低四分位数）在粗分析中无相关性，但在调整后，认知障碍的风险增加。
巴西南部老年人维生素 D 最低四分位数与可能的认知障碍直接相关。需要更多的研究来调查维持足够的血清水平是否可能是预防与年龄相关的神经障碍的重要因素，并验证是否需要为该年龄组设定新的截止值。
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