Brandl Beate, Skurk Thomas, Rennekamp Rachel, Hannink Anne, Kiesswetter Eva, Freiherr Jessica, Ihsen Susanne, Roosen Jutta, Klingenspor Martin, Haller Dirk, Krautwurst Dietmar, Hofmann Thomas, Linseisen Jakob, Volkert Dorothee, Hauner Hans
ZIEL - Institute for Food & Health, Technical University of Munich, Freising, Germany.
Nutritional Medicine, Else Kroener-Fresenius-Centre for Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany.
Front Nutr. 2020 Oct 28;7:582387. doi: 10.3389/fnut.2020.582387. eCollection 2020.
Nutritional habits and requirements are changing over the lifespan, but the dynamics of nutritional issues and the diet-health relationship in the major stages of the human life cycle are not sufficiently understood. A human phenotyping research platform for nutrition studies was established to recruit and phenotype selected population groups across different stages of life. The project is the backbone of the highly interdisciplinary competence cluster of nutrition research aiming to identify dietary determinants of a healthy life throughout the lifespan and to develop healthier and tasty convenience foods with high consumer acceptance. The phenotyping program included anthropometry, body composition analysis, assessment of energy metabolism, health and functional status, multisensory perception, metabolic phenotyping, lifestyle, sociodemography, chronobiology, and assessment of dietary intake including food preferences and aversions. In total, 503 healthy volunteers at four defined phases of life including 3-5-year old children ( = 44), young adults aged 18-25 years ( = 94), adults aged 40-65 years ("middle agers," = 205), and older adults aged 75-85 years ( = 160) were recruited and comprehensively phenotyped. Plasma, serum, buffy coat, urine, feces and saliva samples were collected and stored at -80°C. Significant differences in anthropometric and metabolic parameters between the four groups were found. A major finding was the decrease in fat-free mass and the concomitant increase in % body fat in both sexes across the adult lifespan. The dataset will provide novel information on differences in diet-related parameters over the lifespan and is available for targeted analyses. We expect that this novel platform approach will have implications for the development of innovative food products tailored to promote healthy eating throughout life. DRKS, DRKS00009797. Registered on 20 January 2016, https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&_ID=DRKS00009797.
营养习惯和需求在人的一生中不断变化，但人们对人类生命周期主要阶段中营养问题的动态变化以及饮食与健康的关系尚未有充分的了解。为此，建立了一个用于营养研究的人类表型研究平台，以招募处于不同生命阶段的特定人群并对其进行表型分析。该项目是营养研究高度跨学科能力集群的核心，旨在确定一生中健康生活的饮食决定因素，并开发出消费者接受度高的更健康、美味的方便食品。表型分析项目包括人体测量、身体成分分析、能量代谢评估、健康和功能状态评估、多感官感知、代谢表型分析、生活方式、社会人口统计学、生物钟学以及饮食摄入量评估，包括食物偏好和厌恶。总共招募了503名处于四个特定生命阶段的健康志愿者，分别是3至5岁的儿童（n = 44）、18至25岁的年轻人（n = 94）、40至65岁的成年人（“中年人”，n = 205）和75至85岁的老年人（n = 160），并对他们进行了全面的表型分析。收集了血浆、血清、血沉棕黄层、尿液、粪便和唾液样本，并储存在-80°C下。发现四组之间在人体测量和代谢参数方面存在显著差异。一个主要发现是，在整个成年期，两性的去脂体重均下降，而体脂百分比则相应增加。该数据集将提供有关一生中与饮食相关参数差异的新信息，可用于针对性分析。我们预计，这种新颖的平台方法将对开发旨在促进终生健康饮食的创新食品产生影响。德国临床试验注册中心，DRKS00009797。于2016年1月20日注册，https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&_ID=DRKS00009797 。
