Gerhard I, Vollmar B, Runnebaum B, Klinga K, Haller U, Kubli F
Department of Gynecological Endocrinology, Women's Hospital, University of Heidelberg, F.R.G.
Eur J Obstet Gynecol Reprod Biol. 1987 Dec;26(4):313-28. doi: 10.1016/0028-2243(87)90129-8.
In a prospective study of 847 singleton pregnancies, the importance of various endocrine methods (serum estriol, HPL, SP1, beta-HCG, estradiol-17 beta, urinary estrogen excretion) and of two sonographic measurements (biparietal and thoracic diameter) for the diagnosis of growth retardation in the third trimester was studied. HPL and estriol determinations were best suited for the diagnosis of growth retardation. The thoracic diameter correlated most closely with the birthweight of the newborns. Sensitivity in relationship to growth retardation was between 17 and 35% for the HPL and estriol determinations as well as for both sonographic methods. Specificity was around 90% for these methods. The validity for all methods improved as the time of birth approached. Through the simultaneous measurement of one of the hormones and the thoracic diameter, an antepartal diagnosis of up to 50% of the hypo- and hypertrophic growth disorders was achieved. In the first two years of life a relationship between development and the HPL and estriol concentrations could be observed which was independent of the weight percentile at birth.
在一项对847例单胎妊娠的前瞻性研究中，研究了各种内分泌方法（血清雌三醇、人胎盘催乳素、妊娠特异性β1糖蛋白、β-人绒毛膜促性腺激素、雌二醇-17β、尿雌激素排泄量）以及两种超声测量方法（双顶径和胸径）对诊断晚期妊娠胎儿生长迟缓的重要性。人胎盘催乳素和雌三醇测定最适合用于诊断生长迟缓。胸径与新生儿出生体重的相关性最为密切。人胎盘催乳素和雌三醇测定以及两种超声检查方法对生长迟缓的敏感性在17%至35%之间。这些方法的特异性约为90%。随着出生时间临近，所有方法的有效性均有所提高。通过同时测量一种激素和胸径，可在产前诊断出高达50%的生长不足和生长过度疾病。在生命的头两年，可以观察到发育与血清人胎盘催乳素和雌三醇浓度之间的关系，且这种关系与出生时的体重百分位数无关。
