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带接种和生命动态的离散时间传染病模型的稳定性和分支。

Stability and bifurcations in a discrete-time epidemic model with vaccination and vital dynamics.

机构信息

Department of Mathematics, Faculty of Mohajer, Isfahan Branch, Technical and Vocational University (TVU), Isfahan, Iran.

Department of Mathematics, Faculty of Science, University of Zabol, Zabol, Iran.

出版信息

BMC Bioinformatics. 2020 Nov 16;21(1):525. doi: 10.1186/s12859-020-03839-1.

Abstract

BACKGROUND

The spread of infectious diseases is so important that changes the demography of the population. Therefore, prevention and intervention measures are essential to control and eliminate the disease. Among the drug and non-drug interventions, vaccination is a powerful strategy to preserve the population from infection. Mathematical models are useful to study the behavior of an infection when it enters a population and to investigate under which conditions it will be wiped out or continued.

RESULTS

A discrete-time SIS epidemic model is introduced that includes a vaccination program. Some basic properties of this model are obtained; such as the equilibria and the basic reproduction number [Formula: see text]. Then the stability of the equilibria is given in terms of [Formula: see text], and the bifurcations of the model are studied. By applying the forward Euler method on the continuous version of the model, a discretized model is obtained and analyzed.

CONCLUSION

It is proven that the disease-free equilibrium and endemic equilibrium are stable if [Formula: see text] and [Formula: see text], respectively. Also, the disease-free equilibrium is globally stable when [Formula: see text]. The system has a transcritical bifurcation when [Formula: see text] and it might also have period-doubling bifurcation. The sufficient conditions for the stability of equilibria in the discretized model are established. The numerical discussions verify the theoretical results.

摘要

背景

传染病的传播非常重要,它改变了人口结构。因此,预防和干预措施对于控制和消除疾病至关重要。在药物和非药物干预措施中,疫苗接种是保护人群免受感染的有力策略。数学模型可用于研究感染进入人群时的行为,并研究在何种条件下它将被消灭或继续存在。

结果

引入了一个包括疫苗接种计划的离散时间 SIS 传染病模型。获得了该模型的一些基本性质,例如平衡点和基本再生数 [Formula: see text]。然后根据 [Formula: see text] 给出平衡点的稳定性,并研究模型的分岔。通过在模型的连续版本上应用前向 Euler 方法,获得并分析了离散化模型。

结论

证明了如果 [Formula: see text] 和 [Formula: see text],则无病平衡点和地方病平衡点分别是稳定的。此外,当 [Formula: see text] 时,无病平衡点是全局稳定的。当 [Formula: see text] 时,系统存在跨越临界分岔,并且可能存在倍周期分岔。建立了离散化模型中平衡点稳定性的充分条件。数值讨论验证了理论结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4039/7667759/a0fe517238a8/12859_2020_3839_Fig1_HTML.jpg

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