Department of Obstetrics and Gynaecology in Linköping, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Occupational and Environmental Medicine Center in Linköping, and Department of Health, Medicine and Caring Sciences, Linköping University, 58185, Linköping, Sweden.
Sci Rep. 2020 Nov 16;10(1):19837. doi: 10.1038/s41598-020-76901-w.
Physical inactivity and the onset of menopause increase the risk of cardiovascular disease amongst postmenopausal women. We aim to investigate the effect of resistance training (RT) on plasma levels of selected cytokines, adipokines, myokines, and sex hormones in postmenopausal women with vasomotor symptoms. This was a sub-study of a randomised controlled trial investigating the effects of RT on vasomotor symptoms in postmenopausal women. Women were randomised to join a 15-week RT program (n = 26) or remain sedentary as control (n = 29). Venous blood samples were taken at week-0 and week-15 for all participants. Enzyme-linked immunosorbent assays and multiple bead assays were used to measure cytokines, adipokines, myokines, and sex hormones in plasma. Plasma measurements of 16 of 33 analytes were within detectable limits. After adjusting for good compliance in the RT group (58% of RT participants), after 15 weeks, significantly lower plasma levels of adiponectin (p < 0.001), lipocalin-2 (p < 0.01) and resistin (p = 0.04) were found. Comparing control and RT women, using change-over-time values, significant increases in median testosterone and sex hormone binding globulin levels were seen in RT women. RT intervention lowers the levels of adipokines, particularly adiponectin, in postmenopausal women with vasomotor symptoms. These results were secondary outcomes of a clinical trial, and further investigations in a larger cohort are essential with the additional control of diet control and body composition analyses. Nevertheless, our study shows RT may be a beneficial intervention in reducing inflammation amongst postmenopausal women.
缺乏身体活动和绝经会增加绝经后女性患心血管疾病的风险。我们旨在研究抗阻训练（RT）对有血管舒缩症状的绝经后妇女的某些细胞因子、脂肪因子、肌因子和性激素血浆水平的影响。这是一项随机对照试验的子研究，该试验研究了 RT 对绝经后妇女血管舒缩症状的影响。将女性随机分为参加 15 周 RT 计划（n = 26）或保持久坐不动作为对照组（n = 29）。所有参与者在第 0 周和第 15 周采集静脉血样。使用酶联免疫吸附测定法和多重珠粒测定法测量血浆中的细胞因子、脂肪因子、肌因子和性激素。33 种分析物中的 16 种的血浆测量值在可检测范围内。在调整了 RT 组的良好依从性（RT 组 58%的参与者）后，经过 15 周，发现脂肪因子（p < 0.001）、脂联素、脂联素（p < 0.01）和抵抗素（p = 0.04）的血浆水平显著降低。与对照组和 RT 组女性相比，使用时间变化值，RT 组女性的睾酮和性激素结合球蛋白水平中位数显著增加。RT 干预降低了有血管舒缩症状的绝经后妇女的脂肪因子水平，特别是脂联素。这些结果是一项临床试验的次要结果，需要在更大的队列中进行进一步的研究，并额外控制饮食控制和身体成分分析。尽管如此，我们的研究表明 RT 可能是减少绝经后妇女炎症的有益干预措施。
