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胃十二指肠免疫反应性胰分泌性胰蛋白酶抑制剂的发生率各异。

Varying occurrence of gastroduodenal immunoreactive pancreatic secretory trypsin inhibitor.

作者信息

Bohe M, Lindström C G, Ohlsson K

机构信息

Department of Surgery, University of Lund, Malmö General Hospital, Sweden.

出版信息

J Clin Pathol. 1987 Nov;40(11):1345-8. doi: 10.1136/jcp.40.11.1345.

DOI:10.1136/jcp.40.11.1345
PMID:3320096
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1141237/
Abstract

Operative specimens from various parts of gastroduodenal mucosa were analysed for immunoreactive pancreatic secretory trypsin inhibitor (PSTI) using a peroxidase-antiperoxidase method. Normal gastric mucosa exhibited a varying degree of PSTI immunoreactivity, which was more pronounced in the foveolar cells of gastric mucosa of fundus type than in the non-pepsinogen producing antrum-pyloric mucosa. With the exception of metaplastic Paneth cells and some goblet cells, the intracellular content of PSTI was low in gastric mucosa with intestinal metaplasia. These findings may indicate that a PSTI immunoreactive substance has a role in the normal defence of the gastric mucosa.

摘要

采用过氧化物酶-抗过氧化物酶法，对取自胃十二指肠黏膜不同部位的手术标本进行免疫反应性胰分泌性胰蛋白酶抑制剂（PSTI）分析。正常胃黏膜呈现出不同程度的PSTI免疫反应性，在胃底型胃黏膜的小凹细胞中比在不产生胃蛋白酶原的胃窦-幽门黏膜中更为明显。除化生的潘氏细胞和一些杯状细胞外，肠化生的胃黏膜中PSTI的细胞内含量较低。这些发现可能表明，一种PSTI免疫反应性物质在胃黏膜的正常防御中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/7d490a4ffe1e/jclinpath00331-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/ed8c01c2286b/jclinpath00331-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/4c69425acea1/jclinpath00331-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/7e98ead39e4d/jclinpath00331-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/bc9d1f63a5ef/jclinpath00331-0081-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/7d490a4ffe1e/jclinpath00331-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/ed8c01c2286b/jclinpath00331-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/4c69425acea1/jclinpath00331-0080-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/7e98ead39e4d/jclinpath00331-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/bc9d1f63a5ef/jclinpath00331-0081-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0197/1141237/7d490a4ffe1e/jclinpath00331-0082-a.jpg

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引用本文的文献

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本文引用的文献

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Primary amino acid sequence similarity between human epidermal growth factor-urogastrone, human pancreatic secretory trypsin inhibitor, and members of porcine secretin family.
体外胰腺腺泡细胞中胰蛋白酶原自身激活的缺失及胰腺分泌性胰蛋白酶抑制剂的免疫定位
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Immunohistochemical demonstration of pancreatic secretory trypsin inhibitor in normal and neoplastic colonic mucosa.正常和肿瘤性结肠黏膜中胰腺分泌性胰蛋白酶抑制剂的免疫组织化学证明
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Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice.
Gut. 1990 Nov;31(11):1318-23. doi: 10.1136/gut.31.11.1318.
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Immunoreactive pancreatic secretory trypsin inhibitor in normal, inflammatory and neoplastic gallbladders.
Gastroenterol Jpn. 1991 Feb;26(1):95-8. doi: 10.1007/BF02779516.
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Quantification of pancreatic secretory trypsin inhibitor in colonic carcinoma and normal adjacent colonic mucosa.结肠癌及癌旁正常结肠黏膜中胰腺分泌性胰蛋白酶抑制剂的定量分析。
J Clin Pathol. 1992 Dec;45(12):1066-9. doi: 10.1136/jcp.45.12.1066.
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Immunocytochemical distribution of trypsinogen and pancreatic secretory trypsin inhibitor in normal and neoplastic tissues in man.人正常组织和肿瘤组织中胰蛋白酶原及胰腺分泌性胰蛋白酶抑制剂的免疫细胞化学分布
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