Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Enterovírus, Rio de Janeiro, RJ, Brasil.
Rev Soc Bras Med Trop. 2020 Nov 13;54:e20190499. doi: 10.1590/0037-8682-0499-2019. eCollection 2020.
Although different etiological agents can cause acute meningoencephalitis, this syndrome is usually associated with viruses. Among these, enteroviruses play a significant role. Here, we describe a fatal case of meningoencephalitis in a previously healthy teenager. Real-time RT-PCR and cell culture assays were performed with serum and cerebrospinal fluid (CSF) from a clinically diagnosed meningoencephalitis case that occurred in Rio de Janeiro State, Brazil. Coxsackievirus B2 (CVB2) was identified. Phylogenetic analysis revealed that the identified CVB2 was genetically related to strains known to cause neurological diseases. This case highlights the importance of continuous laboratory surveillance of central nervous system infections.
虽然不同的病原体可引起急性脑膜脑炎，但该综合征通常与病毒有关。其中，肠道病毒起着重要作用。在此，我们描述了巴西里约热内卢州一例先前健康的青少年患脑膜脑炎的致死病例。对临床诊断为脑膜脑炎的病例的血清和脑脊液进行了实时 RT-PCR 和细胞培养检测，鉴定出柯萨奇病毒 B2（CVB2）。系统进化分析显示，鉴定出的 CVB2 与已知可引起神经疾病的毒株具有遗传相关性。本病例强调了对中枢神经系统感染进行持续实验室监测的重要性。
