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1
Spread of a single plasmid clone to an untreated individual from a person receiving prolonged tetracycline therapy.单个质粒克隆从接受长期四环素治疗的人传播到未接受治疗的个体。
Antimicrob Agents Chemother. 1977 Aug;12(2):219-25. doi: 10.1128/AAC.12.2.219.
2
The persistence of R-plasmid-carrying E. coli in a married couple, one of whom was receiving antibiotics.一对已婚夫妇中携带R质粒的大肠杆菌持续存在，其中一人正在接受抗生素治疗。
Contrib Microbiol Immunol. 1979;6:178-88.
3
Persistence of plasmid-carrying tetracycline-resistant Escherichia coli in a married couple, one of whom was receiving antibiotics.一对夫妇中携带质粒的耐四环素大肠杆菌的持续存在，其中一人正在接受抗生素治疗。
Antimicrob Agents Chemother. 1979 Aug;16(2):225-30. doi: 10.1128/AAC.16.2.225.
4
Changing patterns of plasmid-mediated drug resistance during tetracycline therapy.四环素治疗期间质粒介导的耐药性变化模式。
Antimicrob Agents Chemother. 1977 Mar;11(3):388-91. doi: 10.1128/AAC.11.3.388.
5
R-plasmid transfer in vivo in the absence of antibiotic selection pressure.在没有抗生素选择压力的情况下，R质粒在体内的转移
Antimicrob Agents Chemother. 1976 Oct;10(4):753-61. doi: 10.1128/AAC.10.4.753.
6
Isolation, by tetracycline selection, of small plasmids derived from R-factor R12 in Escherichia coli K-12.通过四环素筛选，从大肠杆菌K-12中的R因子R12分离出小质粒。
J Bacteriol. 1976 Jul;127(1):644-55. doi: 10.1128/jb.127.1.644-655.1976.
7
Selective pressure of tetracyclines on the faecal flora. A comparison between tetracycline and doxycycline.四环素对粪便菌群的选择压力。四环素与强力霉素的比较。
Scand J Infect Dis Suppl. 1976(9):89-93.
8
Antimicrobial resistance of Shiga toxin (verotoxin)-producing Escherichia coli O157:H7 and non-O157 strains isolated from humans, cattle, sheep and food in Spain.从西班牙的人类、牛、羊和食物中分离出的产志贺毒素（维罗毒素）大肠杆菌O157:H7和非O157菌株的抗菌耐药性
Res Microbiol. 2005 Aug;156(7):793-806. doi: 10.1016/j.resmic.2005.03.006. Epub 2005 Apr 22.
9
The effect of long term tetracycline treatment for acne vulgaris on the occurrence of R factors in the intestinal flora of man.
Br J Dermatol. 1976 Sep;95(3):311-6. doi: 10.1111/j.1365-2133.1976.tb07019.x.
10
Studies on R-plasmid-determined drug resistance in serotypes 792 (E. coli O 28a28c:K73) and 145-46 (E. coli O 164).
Zentralbl Bakteriol A. 1980;248(1):38-44.

引用本文的文献

1
Antibiotic abuse: spare the child.抗生素滥用：放过孩子。
Can Med Assoc J. 1980 Jun 7;122(11):1236-8.
2
R-plasmic transfer from Serratia liquefaciens to Escherichia coli in vitro and in vivo in the digestive tract of gnotobiotic mice associated with human fecal flora.在与人类粪便菌群相关的悉生小鼠消化道中，体外及体内条件下从液化沙雷氏菌到大肠杆菌的R质粒转移
Infect Immun. 1980 Jun;28(3):981-90. doi: 10.1128/iai.28.3.981-990.1980.
3
Persistence of plasmid-carrying tetracycline-resistant Escherichia coli in a married couple, one of whom was receiving antibiotics.一对夫妇中携带质粒的耐四环素大肠杆菌的持续存在，其中一人正在接受抗生素治疗。
Antimicrob Agents Chemother. 1979 Aug;16(2):225-30. doi: 10.1128/AAC.16.2.225.
4
Chloramphenicol resistance plasmids in Escherichia coli isolated from diseased piglets.从患病仔猪分离出的大肠杆菌中的氯霉素抗性质粒。
Antimicrob Agents Chemother. 1978 May;13(5):710-5. doi: 10.1128/AAC.13.5.710.

本文引用的文献

1
Purification and properties of bacteriophage MS2 and of its ribonucleic acid.噬菌体MS2及其核糖核酸的纯化与性质
J Mol Biol. 1963 Jul;7:43-54. doi: 10.1016/s0022-2836(63)80017-0.
2
Mutant drug resistant factors of high transmissibility.具有高传播性的突变耐药因子。
Nature. 1967 May 27;214(5091):885-7. doi: 10.1038/214885a0.
3
[Transferable resistance to gentamicin. I. Expression of the resistance character].[对庆大霉素的可转移抗性。I. 抗性特征的表达]
Ann Inst Pasteur (Paris). 1971 Dec;121(6):733-42.
4
Beginning a genetic analysis of conjugational transfer determined by the F factor in Escherichia coli by isolation and characterization of transfer-deficient mutants.通过分离和鉴定转移缺陷型突变体，对大肠杆菌中由F因子决定的接合转移进行遗传分析。
J Bacteriol. 1971 May;106(2):529-38. doi: 10.1128/jb.106.2.529-538.1971.
5
[Stability of coli flora of the healthy human. 1. The occurrence of permanent and changing types].[健康人体大肠菌群的稳定性。1. 固定型和变化型的出现情况]
Arch Hyg Bakteriol. 1969 Aug;153(4):342-8.
6
Properties of a R factor which originated in Pseudomonas aeruginosa 1822.源自铜绿假单胞菌1822的一种R因子的特性。
J Bacteriol. 1972 May;110(2):529-37. doi: 10.1128/jb.110.2.529-537.1972.
7
R Factors in Escherichia coli in faeces after oral chemotherapy in general practice.
Lancet. 1971 Feb 13;1(7694):312-5. doi: 10.1016/s0140-6736(71)91042-7.
8
Analytical isoelectric focusing of R factor-determined beta-lactamases: correlation with plasmid compatibility.R因子决定的β-内酰胺酶的分析性等电聚焦：与质粒相容性的相关性
J Bacteriol. 1976 Feb;125(2):713-8. doi: 10.1128/jb.125.2.713-718.1976.
9
Phage lambda receptor chromosomes for DNA fragments made with restriction endonuclease III of Haemophilus influenzae and restriction endonuclease I of Escherichia coli.用于由流感嗜血杆菌的限制性内切核酸酶III和大肠杆菌的限制性内切核酸酶I制备的DNA片段的噬菌体λ受体染色体。
J Mol Biol. 1975 Nov 5;98(3):551-64. doi: 10.1016/s0022-2836(75)80086-6.
10
Studies on the cleavage of bacteriophage lambda DNA with EcoRI Restriction endonuclease.用EcoRI限制性内切酶切割噬菌体λ DNA的研究。
J Mol Biol. 1975 Jan 25;91(3):315-28. doi: 10.1016/0022-2836(75)90383-6.

单个质粒克隆从接受长期四环素治疗的人传播到未接受治疗的个体。

Spread of a single plasmid clone to an untreated individual from a person receiving prolonged tetracycline therapy.

作者信息

Petrocheilou V, Richmond M H, Bennett P M

出版信息

Antimicrob Agents Chemother. 1977 Aug;12(2):219-25. doi: 10.1128/AAC.12.2.219.

DOI:10.1128/AAC.12.2.219
PMID:332073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429888/
Abstract

The aerobic gram-negative intestinal flora of two individuals living in close proximity was followed for 17 months. One of these persons was receiving a prolonged tetracycline treatment for acne vulgaris and was colonized by tetracycline-resistant Escherichia coli strains throughout the survey. The other person studied received no antibiotics during the period in question, but was frequently found to excrete a number of E. coli strains harboring tetracycline-resistant plasmids. The two E. coli strains (O75.H7 and O23.H16) excreted from both persons most frequently were indistinguishable, and so were the R-plasmids they carried. This suggests that R-plasmid-carrying E. coli may spread from individuals under treatment to close relatives that have not been treated.

摘要

对居住在附近的两个人的需氧革兰氏阴性肠道菌群进行了17个月的跟踪研究。其中一人因寻常痤疮接受了长期四环素治疗，在整个调查期间被四环素耐药性大肠杆菌菌株定植。另一研究对象在相关期间未接受抗生素治疗，但经常发现其排出多种携带四环素耐药质粒的大肠杆菌菌株。两人最常排出的两种大肠杆菌菌株（O75.H7和O23.H16）无法区分，它们携带的R质粒也是如此。这表明携带R质粒的大肠杆菌可能从接受治疗的个体传播到未接受治疗的近亲。