单个质粒克隆从接受长期四环素治疗的人传播到未接受治疗的个体。
Spread of a single plasmid clone to an untreated individual from a person receiving prolonged tetracycline therapy.
作者信息
Petrocheilou V, Richmond M H, Bennett P M
出版信息
Antimicrob Agents Chemother. 1977 Aug;12(2):219-25. doi: 10.1128/AAC.12.2.219.
Abstract
The aerobic gram-negative intestinal flora of two individuals living in close proximity was followed for 17 months. One of these persons was receiving a prolonged tetracycline treatment for acne vulgaris and was colonized by tetracycline-resistant Escherichia coli strains throughout the survey. The other person studied received no antibiotics during the period in question, but was frequently found to excrete a number of E. coli strains harboring tetracycline-resistant plasmids. The two E. coli strains (O75.H7 and O23.H16) excreted from both persons most frequently were indistinguishable, and so were the R-plasmids they carried. This suggests that R-plasmid-carrying E. coli may spread from individuals under treatment to close relatives that have not been treated.
摘要
对居住在附近的两个人的需氧革兰氏阴性肠道菌群进行了17个月的跟踪研究。其中一人因寻常痤疮接受了长期四环素治疗，在整个调查期间被四环素耐药性大肠杆菌菌株定植。另一研究对象在相关期间未接受抗生素治疗，但经常发现其排出多种携带四环素耐药质粒的大肠杆菌菌株。两人最常排出的两种大肠杆菌菌株（O75.H7和O23.H16）无法区分，它们携带的R质粒也是如此。这表明携带R质粒的大肠杆菌可能从接受治疗的个体传播到未接受治疗的近亲。
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