罗沙米星——一种治疗细菌性前列腺炎的新药。
Rosamicin--a new drug for the treatment of bacterial prostatitis.
作者信息
Baumueller A, Hoyme U, Madsen P O
出版信息
Antimicrob Agents Chemother. 1977 Aug;12(2):240-2. doi: 10.1128/AAC.12.2.240.
Abstract
Rosamicin, a new macrolide substance, was investigated in dogs and humans with regard to its usefulness for the treatment of bacterial prostatitis and compared with the well-known macrolide erythromycin. In dogs with normal and experimentally infected prostates, concentration ratios for rosamicin in prostatic secretion, interstitial fluid (obtained from implanted tissue chambers), and tissue were significantly higher than for erythromycin. The difference was even more pronounced in human prostatic tissue, obtained by transurethral resection. With its broad spectrum against many common urinary pathogens, rosamicin seems to be a promising drug for the treatment of acute and chronic bacterial prostatitis.
摘要
罗沙米星是一种新型大环内酯类物质，对其治疗细菌性前列腺炎的有效性在犬类和人类身上进行了研究，并与著名的大环内酯类药物红霉素进行了比较。在前列腺正常和经实验感染的犬类中，罗沙米星在前列腺分泌物、间质液（从植入的组织腔室获取）和组织中的浓度比显著高于红霉素。在经尿道切除获取的人类前列腺组织中，这种差异更为明显。罗沙米星对许多常见尿路病原体具有广谱抗菌作用，似乎是治疗急性和慢性细菌性前列腺炎的一种有前景的药物。
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