蔷薇霉素、交沙霉素、红霉素和克林霉素对淋病奈瑟菌β-内酰胺酶阴性和β-内酰胺酶阳性菌株的体外活性。
In vitro activity of rosamicin, josamycin, erythromycin, and clindamycin against beta-lactamase-nagative and beta-lactamase-positive strains of Neisseria gonorrhoeae.
作者信息
Biddle J W, Thornsberry C
出版信息
Antimicrob Agents Chemother. 1979 Feb;15(2):243-5. doi: 10.1128/AAC.15.2.243.
Abstract
Randomly selected strains of beta-lactamase-negative and beta-lactamase-positive Neisseria gonorrhoeae were tested by an agar dilution method for susceptibility to rosamicin, josamycin, erythromycin, clindamycin, and penicillin G. Rosamicin was more active than erythromycin, which was more active than josamycin or clindamycin; the latter two were similar in their activity. The susceptibility to the macrolide antibiotics and clindamycin was independent of beta-lactamase production, but the penicillin minimal inhibitory concentrations were higher in the beta-lactamase-positive group because of the enzyme.
摘要
采用琼脂稀释法对随机选取的β-内酰胺酶阴性和β-内酰胺酶阳性淋病奈瑟菌菌株进行了对蔷薇霉素、交沙霉素、红霉素、克林霉素和青霉素G的敏感性测试。蔷薇霉素比红霉素活性更强，红霉素比交沙霉素或克林霉素活性更强；后两者活性相似。对大环内酯类抗生素和克林霉素的敏感性与β-内酰胺酶的产生无关，但由于β-内酰胺酶的存在，β-内酰胺酶阳性组的青霉素最低抑菌浓度更高。
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