Gorbunova Anna S, Yapryntseva Maria A, Denisenko Tatiana V, Zhivotovsky Boris
Faculty of Basic Medicine, Lomonosov Moscow State University, 119192 Moscow, Russia.
Karolinska Institutet, Institute of Environmental Medicine, SE-17177 Stockholm, Sweden.
Cancers (Basel). 2020 Nov 16;12(11):3390. doi: 10.3390/cancers12113390.
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most aggressive types of cancer, which is often diagnosed at an advanced stage. Therefore, there is still urgent demand for reliable biochemical markers for lung cancer and its efficient treatment. Mitochondria functioning and mitochondrial proteins, including BNIP3, have a strong impact on lung cancer development and progression. Here, we summarized current knowledge about the BNIP3 gene and protein features and their role in cancer progression, especially in lung cancer in order to develop new therapeutic approaches associated with BNIP3.
Bcl-2/腺病毒E1B 19kDa相互作用蛋白3（BNIP3）是Bcl-2家族中仅含BH3结构域的促凋亡蛋白。最初，BNIP3被描述为心肌细胞和神经元中缺氧诱导凋亡性细胞死亡的介质之一。除了凋亡作用外，BNIP3在不同肿瘤类型的自噬、代谢途径和转移相关过程中也起着关键作用。肺癌是侵袭性最强的癌症类型之一，通常在晚期才被诊断出来。因此，对于肺癌可靠的生化标志物及其有效治疗仍有迫切需求。线粒体功能及包括BNIP3在内的线粒体蛋白对肺癌的发生和发展有很大影响。在此，我们总结了关于BNIP3基因和蛋白特征及其在癌症进展，尤其是肺癌进展中的作用的现有知识，以便开发与BNIP3相关的新治疗方法。
