大鼠吲哚美辛诱导胃溃疡模型中主要化合物的分离及其胃保护活性
Isolation of Major Compounds and Gastroprotective Activity of on Indomethacin Induced Gastric Ulcers in Rats.
作者信息
Karaoglan Esen Sezen, Bayir Yasin, Albayrak Abdulmecit, Toktay Erdem, Ozgen Ufuk, Kazaz Cavit, Kahramanlar Aysenur, Cadirci Elif
机构信息
Department of Pharmaceutical Botany, Ataturk University Faculty of Pharmacy, Erzurum, Turkey.
Department of Biochemistry, Ataturk University Faculty of Pharmacy, Erzurum, Turkey.
出版信息
Eurasian J Med. 2020 Oct;52(3):249-253. doi: 10.5152/eurasianjmed.2020.19243.
OBJECTIVE
The genus, which belongs to the Rosaceae family, is known as Lady's mantle and is commonly used in traditional medicine. This study was designed to investigate the major metabolites isolation and gastroprotective effects of .
MATERIALS AND METHODS
Phytochemical studies were carried out using column chromatography on . The gastroprotective effect of ethanol extract of this plant was tested on indomethacin-induced gastric ulcer model in rats. In addition, superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) parameters in the stomach tissue were examined.
RESULTS
Quercetin-3-O-glucuronide, apigenin, and catechin were isolated from aerial parts of . When macroscopic ulcer index and histopathological results were analyzed, the extract at 200 mg/kg dose was found to be most effective. All doses of extract reduced MDA level and enhanced SOD activity and GSH level.
CONCLUSION
The results of this study showed that has significant antiulcer activity. This effect was thought to be caused by antioxidant properties of flavonoids.
目的
该属植物属于蔷薇科，被称为斗篷草，常用于传统医学。本研究旨在调查其主要代谢产物的分离及其胃保护作用。
材料与方法
采用柱色谱法对……进行植物化学研究。用该植物的乙醇提取物对吲哚美辛诱导的大鼠胃溃疡模型进行胃保护作用测试。此外，检测胃组织中的超氧化物歧化酶（SOD）、丙二醛（MDA）和谷胱甘肽（GSH）参数。
结果
从……地上部分分离出槲皮素-3-O-葡萄糖醛酸苷、芹菜素和儿茶素。分析宏观溃疡指数和组织病理学结果时，发现200mg/kg剂量的提取物最有效。所有剂量的提取物均降低了MDA水平，增强了SOD活性和GSH水平。
结论
本研究结果表明……具有显著的抗溃疡活性。这种作用被认为是由黄酮类化合物的抗氧化特性引起的。
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