MOE Key Laboratory of Marine Genetics and Breeding and Sars-Fang Centre, Ocean University of China, Qingdao 266003, China.
Laboratory for Marine Biology and Biotechnology, Pilot Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
Nucleic Acids Res. 2021 Jan 8;49(D1):D988-D997. doi: 10.1093/nar/gkaa918.
Mollusca represents the second largest animal phylum but remains poorly explored from a genomic perspective. While the recent increase in genomic resources holds great promise for a deep understanding of molluscan biology and evolution, access and utilization of these resources still pose a challenge. Here, we present the first comprehensive molluscan genomics database, MolluscDB (http://mgbase.qnlm.ac), which compiles and integrates current molluscan genomic/transcriptomic resources and provides convenient tools for multi-level integrative and comparative genomic analyses. MolluscDB enables a systematic view of genomic information from various aspects, such as genome assembly statistics, genome phylogenies, fossil records, gene information, expression profiles, gene families, transcription factors, transposable elements and mitogenome organization information. Moreover, MolluscDB offers valuable customized datasets or resources, such as gene coexpression networks across various developmental stages and adult tissues/organs, core gene repertoires inferred for major molluscan lineages, and macrosynteny analysis for chromosomal evolution. MolluscDB presents an integrative and comprehensive genomics platform that will allow the molluscan community to cope with ever-growing genomic resources and will expedite new scientific discoveries for understanding molluscan biology and evolution.
软体动物门是第二大动物门，但从基因组学的角度来看，其研究仍不够深入。虽然最近基因组资源的增加为深入了解软体动物的生物学和进化提供了巨大的潜力，但这些资源的获取和利用仍然是一个挑战。在这里，我们介绍了第一个全面的软体动物基因组学数据库 MolluscDB（http://mgbase.qnlm.ac），它整合了当前的软体动物基因组/转录组资源，并提供了方便的工具，用于多层次的综合和比较基因组分析。MolluscDB 可以从多个方面系统地查看基因组信息，例如基因组组装统计信息、基因组系统发育、化石记录、基因信息、表达谱、基因家族、转录因子、转座子和线粒体基因组组织信息。此外，MolluscDB 还提供了有价值的定制数据集或资源，例如跨各种发育阶段和成年组织/器官的基因共表达网络、主要软体动物谱系推断的核心基因库，以及染色体进化的宏同线性分析。MolluscDB 提供了一个综合性的基因组学平台，使软体动物界能够应对不断增长的基因组资源，并加速新的科学发现，以了解软体动物的生物学和进化。
