Aaron Sanjith, Lakshmanan Jeyaseelan, Sudarsanam Thambu D, Benjamin Kenneth, Durairaj Jothilakshmi, Mathew Vivek, Sivadasan Ajith, Prabhakar A T, Keshava Shyam Kumar N, Mannam Pavitra R, Kirubakaran Prabhu, Muliyil Jayaprakash, Alexander Mathew
Department of Neurology, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Department of Biostatistics, Christian Medical College Hospital, Vellore, Tamil Nadu, India.
Ann Indian Acad Neurol. 2020 Jul-Aug;23(4):522-527. doi: 10.4103/aian.AIAN_409_19. Epub 2019 Jul 11.
Studies looking at seasonal variation on cerebral venous thrombosis (CVT) are few with conflicting conclusions. In this region-specific study, we looked for climatic influence and seasonal trends on the incidence of CVT.
Imaging proven adult CVT cases treated over a period of 18 years from a specific geographical location with similar seasons and climatic conditions were studied. Metrological parameters prepared using 30 years of data was used. Quantum geographical information system (QGIS software) and SPSS v 22 were used for patient plotting and analysis.
Total of 970 cases were studied. The incidence was significantly higher in summer 411 (42.3%) compared with autumn 317 (32.7%) and winter 242 (25.05); = 0.038. This trend was consistent across all the 18 years in time series analysis. Mean age was 33.5 years (range 18-88 years). A significant majority 673 (69.4%) were below 40 years of age; = 0.012. Females constituted 394 (40.6%) of cases. Postpartum CVT cases constituted 237 (30%). Interaction analysis showed younger age (<40 years) were more vulnerable for CVT in summer; = 0.009. There was no seasonal influence on postpartum CVT. Apart for a weak positive correlation between rain fall ( = 0.18, < 0.01); humidity and cloud cover was not influencing the incidence.
Higher ambient temperatures were consistently associated with higher incidence of CVT. This is the largest region-specific study on CVT in the world. These results may be applicable to other regions with similar climatic conditions.
关于脑静脉血栓形成（CVT）季节变化的研究较少，且结论相互矛盾。在这项区域特异性研究中，我们探究了气候对CVT发病率的影响以及季节趋势。
对来自特定地理位置、季节和气候条件相似的18年间经影像学证实的成年CVT病例进行研究。使用了基于30年数据编制的气象参数。采用量子地理信息系统（QGIS软件）和SPSS v 22进行患者绘图与分析。
共研究了970例病例。夏季发病率显著高于秋季和冬季，夏季为411例（42.3%），秋季为317例（32.7%），冬季为242例（25.05%）；P = 0.038。在时间序列分析中，这一趋势在整个18年中保持一致。平均年龄为33.5岁（范围18 - 88岁）。绝大多数673例（69.4%）年龄在40岁以下；P = 0.012。女性占病例的394例（40.6%）。产后CVT病例占237例（30%）。交互分析显示，年龄较小（<40岁）的人群在夏季更易发生CVT；P = 0.009。产后CVT没有季节影响。除降雨量之间存在微弱正相关（r = 0.18，P < 0.01）外，湿度和云量对发病率没有影响。
较高的环境温度一直与较高的CVT发病率相关。这是世界上最大的关于CVT的区域特异性研究。这些结果可能适用于其他气候条件相似的地区。
