Hallén A, Påhlson C, Forsum U
Department of Dermatology and Venereolgy, University Hospital, University of Uppsala, Sweden.
Genitourin Med. 1987 Dec;63(6):386-9. doi: 10.1136/sti.63.6.386.
The diagnostic criteria of bacterial vaginosis (BV) and the prevalence of Mobiluncus spp as detected by monoclonal antibodies were investigated in all new women patients attending the sexually transmitted disease (STD) clinic in Uppsala during a four month period. Of 455 patients, 164 fulfilled the generally accepted criteria for BV, but in 57 of them simultaneous infection with a recognised pathogen was diagnosed. BV was thus the only clinical diagnosis in 107 (24%) of the women. The sniff test and clue cells in the wet smear were the two criteria most relevant for the diagnosis of BV. The sniff test was positive in 95% (156) of the 164 patients with BV and negative in all other cases. The corresponding figure for the clue cells was 98% (160 of 164), but clue cells were also detected in 19 patients without BV. Though 99% (162) of women with BV had a vaginal pH of more than 4.5, so did 83 women without BV. Only 59% (96) of women fulfilling the criteria of BV had a characteristic discharge. Mobiluncus spp were present in 20% (90) of the 455 women and in 50% (53) of the 107 women with BV only. Of the 90 Mobiluncus spp isolates, M curtisii comprised 44% (40), M mulieris 34% (31), and both strains together 21% (19). Mobiluncus spp were detected with monoclonal antibodies in 35 women who had no motile curved rods on wet smear microscopy. Furthermore, Mobiluncus spp were often detected in women infected with recognised pathogens, as well as in a few women without signs of genital infection.
在四个月的时间里，对乌普萨拉性传播疾病（STD）诊所所有新就诊的女性患者进行了研究，以调查细菌性阴道病（BV）的诊断标准以及通过单克隆抗体检测到的动弯杆菌属的患病率。在455名患者中，164名符合BV的普遍接受标准，但其中57名同时被诊断出感染了一种公认的病原体。因此，BV是107名（24%）女性的唯一临床诊断。嗅试验和湿涂片镜检中的线索细胞是与BV诊断最相关的两个标准。在164名BV患者中，95%（156名）的嗅试验呈阳性，其他所有病例均为阴性。线索细胞的相应比例为98%（164名中的160名），但在19名无BV的患者中也检测到了线索细胞。虽然99%（162名）的BV女性阴道pH值大于4.5，但83名无BV的女性也是如此。仅59%（96名）符合BV标准的女性有特征性分泌物。在455名女性中，20%（90名）存在动弯杆菌属，仅在107名BV女性中的50%（53名）存在。在90株动弯杆菌属分离株中，柯氏动弯杆菌占44%（40株），尤氏动弯杆菌占34%（31株），两种菌株共同占21%（19株）。在35名湿涂片显微镜检查未发现活动弯曲杆菌的女性中，通过单克隆抗体检测到了动弯杆菌属。此外，在感染公认病原体的女性以及少数无生殖器感染迹象的女性中也经常检测到动弯杆菌属。
