Schwebke J R, Morgan S C, Hillier S L
Division of Infectious Diseases, University of Alabama at Birmingham 35294-0006, USA.
Clin Diagn Lab Immunol. 1996 Sep;3(5):567-9. doi: 10.1128/cdli.3.5.567-569.1996.
While bacterial vaginosis (BV) is a polymicrobial syndrome, Mobiluncus spp. are the organisms most highly associated with this condition. It is possible that serum antibody to Mobiluncus spp. could be used as a serological marker for BV. Using immunofluorescence techniques, we studied the prevalence of antibody to M. curtisii among three cohorts-pregnant women, pediatric patients, and sexually inexperienced women. The prevalence of antibody in each of these three groups was 75, 6, and 0%, respectively. Of the three pediatric patients with antibody to Mobiluncus curtisii, two were neonates, and the only class of antibody detected was immunoglobulin G. Among the cohort of pregnant women, the presence of antibody could not be correlated with a clinical history of BV. Serum antibody to M. curtisii could be a useful serological marker for BV. The lack of correlation of antibody positivity to historical information regarding BV suggests that unrecognized or undiagnosed episodes of BV may be common.
虽然细菌性阴道病（BV）是一种多种微生物引起的综合征，但动弯杆菌属是与这种疾病关联最为密切的微生物。抗动弯杆菌属的血清抗体有可能用作BV的血清学标志物。我们运用免疫荧光技术，研究了三组人群——孕妇、儿科患者和无性经验女性——中抗柯氏动弯杆菌抗体的流行情况。这三组人群中抗体的流行率分别为75%、6%和0%。在三名有抗柯氏动弯杆菌抗体的儿科患者中，两名是新生儿，检测到的唯一一类抗体是免疫球蛋白G。在孕妇队列中，抗体的存在与BV临床病史并无关联。抗柯氏动弯杆菌的血清抗体可能是一种有用的BV血清学标志物。抗体阳性与BV既往信息缺乏相关性，这表明未被识别或未被诊断的BV发作可能很常见。
