ecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance.
作者信息
Zeng Xixi, Wan Maoping, Wu Jianmin
机构信息
Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, P.R. China.
出版信息
Signal Transduct Target Ther. 2020 Nov 24;5(1):277. doi: 10.1038/s41392-020-00403-4.
Abstract
摘要
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本文引用的文献
1
Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers.染色体外 DNA 与多种癌症中的癌基因扩增和不良预后相关。
Nat Genet. 2020 Sep;52(9):891-897. doi: 10.1038/s41588-020-0678-2. Epub 2020 Aug 17.
2
Classification of extrachromosomal circular DNA with a focus on the role of extrachromosomal DNA (ecDNA) in tumor heterogeneity and progression.以染色体外环状 DNA 分类为重点，探讨染色体外 DNA（ecDNA）在肿瘤异质性和进展中的作用。
Biochim Biophys Acta Rev Cancer. 2020 Aug;1874(1):188392. doi: 10.1016/j.bbcan.2020.188392. Epub 2020 Jul 28.
3
Circular ecDNA promotes accessible chromatin and high oncogene expression.环状 ecDNA 促进染色质可及性和高致癌基因表达。
Nature. 2019 Nov;575(7784):699-703. doi: 10.1038/s41586-019-1763-5. Epub 2019 Nov 20.
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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.染色体外致癌基因扩增驱动肿瘤进化和基因异质性。
Nature. 2017 Mar 2;543(7643):122-125. doi: 10.1038/nature21356. Epub 2017 Feb 8.
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MOLECULAR SIZE AND CIRCULARITY OF DNA IN CELLS OF MAMMALS AND HIGHER PLANTS.哺乳动物和高等植物细胞中DNA的分子大小与环状结构
Proc Natl Acad Sci U S A. 1965 Feb;53(2):356-62. doi: 10.1073/pnas.53.2.356.
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