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羟丙基-β-环糊精在常规体内应用中对液体制剂和半固体制剂亚微乳生理皮肤参数的影响。

Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application.

机构信息

Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090, Vienna, Austria.

Department of Clinical Pharmacology, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria.

出版信息

Int J Cosmet Sci. 2021 Apr;43(2):263-268. doi: 10.1111/ics.12674. Epub 2021 Jan 3.

DOI:10.1111/ics.12674
PMID:33236374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8246995/
Abstract

OBJECTIVE

The aim of the present study was to evaluate the effect of hydroxypropyl-β-cyclodextrin (HP-β-CD) in cosmetic submicron emulsions and submicron emulsion gels on physiological skin parameters during regular application in a clinical set-up.

METHODS

Formulation morphology was investigated using cryo-transmission electron microscopy. Stability of the employed formulations was determined by photon correlation spectroscopy, measurement of pH and rheological properties. Effect on physiological skin parameters was evaluated during regular application over four weeks in a parallel group study (n = 15, healthy forearm skin) with a Corneometer, Sebumeter, skin-pH-Meter, Aquaflux and an Epsilon sensor. Confocal Raman spectroscopy was employed to monitor urea and NMF levels.

RESULTS

Both submicron emulsions and gels showed satisfying storage stability irrespective of cyclodextrin incorporation. No statistically significant effects on skin barrier function and any of the observed parameters were obtained, indicating good skin tolerability of all tested formulations.

CONCLUSION

Results suggest good skin tolerability of the developed cosmetic submicron emulsions and gels with HP-β-CD.

摘要

目的

本研究旨在评估羟丙基-β-环糊精（HP-β-CD）在化妆品亚微米乳液和亚微米乳液凝胶中的作用，以及在临床环境下常规使用时对生理皮肤参数的影响。

方法

使用冷冻传输电子显微镜研究制剂形态。通过光子相关光谱法、pH 值测量和流变性质来确定所采用制剂的稳定性。在一项平行组研究（n=15，健康前臂皮肤）中，在四周的常规应用过程中评估对生理皮肤参数的影响，使用 Corneometer、Sebumeter、皮肤 pH 计、Aquaflux 和 Epsilon 传感器。采用共焦拉曼光谱法监测尿素和 NMF 水平。

结果

两种亚微米乳液和凝胶均表现出令人满意的储存稳定性，与环糊精的掺入无关。对皮肤屏障功能和任何观察到的参数均未得到统计学上显著的影响，表明所有测试制剂均具有良好的皮肤耐受性。

结论

结果表明，开发的含有 HP-β-CD 的化妆品亚微米乳液和凝胶具有良好的皮肤耐受性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/4e5861f7c9bc/ICS-43-263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/071dcadd9ab8/ICS-43-263-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/3ec5909867da/ICS-43-263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/c2db7593478b/ICS-43-263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/4e5861f7c9bc/ICS-43-263-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/071dcadd9ab8/ICS-43-263-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/3ec5909867da/ICS-43-263-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/c2db7593478b/ICS-43-263-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1496/8246995/4e5861f7c9bc/ICS-43-263-g002.jpg

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