Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea.
Sci Rep. 2020 Nov 25;10(1):20568. doi: 10.1038/s41598-020-77584-z.
The purpose of our study was to investigate the relationship between plasma growth differentiation factor-15 (GDF-15) concentrations and diabetic retinopathy in patients with type 2 diabetes mellitus (DM). We evaluated 235 patients with type 2 DM in a cross-sectional study. Significantly increased levels of the plasma GDF-15 were found in individuals with diabetic retinopathy versus those without. According to the degree of diabetic retinopathy, there was a significant difference in the average plasma GDF-15 levels (no diabetic retinopathy, 1114 ng/L; nonproliferative diabetic retinopathy, 1327 ng/L; proliferative diabetic retinopathy, 1445 ng/L; p for trend = 0.035) after adjustments for confounders. Logistic regression analyses indicated that plasma GDF-15 concentrations were significantly associated with diabetic retinopathy (odds ratio per 1 standard deviation increment in the log-transformed value, 1.78; 95% confidence interval, 1.05-3.03, p = 0.032). Our study showed a significant positive relationship between plasma GDF-15 concentrations and diabetic retinopathy in type 2 DM patients.
我们的研究目的是探讨 2 型糖尿病患者血浆生长分化因子 15（GDF-15）浓度与糖尿病视网膜病变之间的关系。我们在一项横断面研究中评估了 235 例 2 型糖尿病患者。与无糖尿病视网膜病变者相比，糖尿病视网膜病变患者的血浆 GDF-15 水平显著升高。根据糖尿病视网膜病变的程度，平均血浆 GDF-15 水平存在显著差异（无糖尿病视网膜病变者为 1114ng/L；非增生性糖尿病视网膜病变者为 1327ng/L；增生性糖尿病视网膜病变者为 1445ng/L；趋势 p 值=0.035），调整混杂因素后。Logistic 回归分析表明，血浆 GDF-15 浓度与糖尿病视网膜病变显著相关（log 转换值每增加 1 个标准差，比值比为 1.78；95%置信区间为 1.05-3.03，p=0.032）。我们的研究表明，2 型糖尿病患者血浆 GDF-15 浓度与糖尿病视网膜病变呈显著正相关。
