School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, 637457, Singapore.
Chem Soc Rev. 2021 Jan 21;50(2):1111-1137. doi: 10.1039/d0cs00664e. Epub 2020 Nov 27.
Second near-infrared photothermal therapy (NIR-II PTT, 1000-1500 nm) has recently emerged as a new phototherapeutic modality with the advantages of deeper penetration, less energy dissipation and minimal normal-tissue toxicity over traditional first NIR PTT (750-1000 nm). However, suboptimal photothermal conversion and limited therapeutic efficacy remain the major challenges for NIR-II PTT. With the convergence in materials science, nanomedicine and biology, multifunctional NIR-II photothermal inorganic or organic materials have been extensively developed to combine NIR-II PTT with other therapeutic modalities for improved efficacies in treating life-threatening diseases including cancer and infection. This review summarizes the recent advances of NIR-II photothermal combinational theranostics pertinent to chemotherapy, immunotherapy, radiotherapy, and photodynamic, sonodynamic, chemodynamic, gene, gas, ionic, vascular and magnetothermal therapy. Potential obstacles and perspectives for future research and clinical translation of this new theranostic modality are also discussed.
第二代近红外光热治疗（NIR-II PTT，1000-1500nm）作为一种新的光疗模式，具有穿透更深、能量耗散更少、对正常组织毒性最小的优点，优于传统的第一代近红外光热治疗（750-1000nm）。然而，光热转换效果不佳和治疗效果有限仍然是 NIR-II PTT 的主要挑战。随着材料科学、纳米医学和生物学的融合，多功能 NIR-II 光热无机或有机材料得到了广泛的开发，将 NIR-II PTT 与其他治疗模式相结合，以提高治疗包括癌症和感染在内的危及生命的疾病的疗效。本综述总结了与化学疗法、免疫疗法、放射疗法以及光动力疗法、声动力疗法、化学动力学疗法、基因疗法、气体疗法、离子疗法、血管热疗和磁热疗相关的 NIR-II 光热联合治疗的最新进展。还讨论了这种新的治疗模式未来研究和临床转化的潜在障碍和前景。
