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新冠病毒感染患者的风险因素预测、临床结局和死亡率。

Risk factors prediction, clinical outcomes, and mortality in COVID-19 patients.

机构信息

Institute for Intelligent Systems Research and Innovation (IISRI), Deakin University, Victoria, Australia.

Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

出版信息

J Med Virol. 2021 Apr;93(4):2307-2320. doi: 10.1002/jmv.26699. Epub 2020 Dec 17.

Abstract

Preventing communicable diseases requires understanding the spread, epidemiology, clinical features, progression, and prognosis of the disease. Early identification of risk factors and clinical outcomes might help in identifying critically ill patients, providing appropriate treatment, and preventing mortality. We conducted a prospective study in patients with flu-like symptoms referred to the imaging department of a tertiary hospital in Iran between March 3, 2020, and April 8, 2020. Patients with COVID-19 were followed up after two months to check their health condition. The categorical data between groups were analyzed by Fisher's exact test and continuous data by Wilcoxon rank-sum test. Three hundred and nineteen patients (mean age 45.48 ± 18.50 years, 177 women) were enrolled. Fever, dyspnea, weakness, shivering, C-reactive protein, fatigue, dry cough, anorexia, anosmia, ageusia, dizziness, sweating, and age were the most important symptoms of COVID-19 infection. Traveling in the past 3 months, asthma, taking corticosteroids, liver disease, rheumatological disease, cough with sputum, eczema, conjunctivitis, tobacco use, and chest pain did not show any relationship with COVID-19. To the best of our knowledge, a number of factors associated with mortality due to COVID-19 have been investigated for the first time in this study. Our results might be helpful in early prediction and risk reduction of mortality in patients infected with COVID-19.

摘要

预防传染病需要了解疾病的传播、流行病学、临床特征、进展和预后。早期识别危险因素和临床结果可能有助于识别重症患者,提供适当的治疗,并预防死亡。我们对 2020 年 3 月 3 日至 2020 年 4 月 8 日期间伊朗一家三级医院放射科就诊的流感样症状患者进行了前瞻性研究。对 COVID-19 患者进行了两个月的随访,以检查其健康状况。采用 Fisher 精确检验对组间分类数据进行分析,采用 Wilcoxon 秩和检验对连续数据进行分析。共纳入 319 例患者(平均年龄 45.48±18.50 岁,177 例女性)。发热、呼吸困难、乏力、寒战、C 反应蛋白、乏力、干咳、厌食、嗅觉丧失、味觉丧失、头晕、出汗和年龄是 COVID-19 感染的最重要症状。在过去 3 个月内旅行、哮喘、使用皮质类固醇、肝脏疾病、风湿病、咳嗽伴咳痰、湿疹、结膜炎、吸烟和胸痛与 COVID-19 无关。据我们所知,本研究首次调查了与 COVID-19 死亡相关的许多因素。我们的研究结果可能有助于早期预测和降低 COVID-19 感染患者的死亡率。

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