Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Department of Cancer Biology, National Cancer Institute, Cairo University, Cairo, Egypt.
Asian Pac J Cancer Prev. 2020 Nov 1;21(11):3279-3284. doi: 10.31557/APJCP.2020.21.11.3279.
Breast cancer is one of the most relevant malignancies among women. Early diagnosis and accurate staging of breast cancer is important for the selection of an appropriate therapeutic strategy and achieving a better outcome.
This study aimed to explore the significance of some non-invasive biomarkers in the early diagnosis and staging of Egyptian breast cancer patients.
A total of 135 female patients with physically and pathologically confirmed breast cancer and 40 unrelated controls as well as 40 patients with benign breast mass were enrolled in this study. The malignant breast cancer group was further divided into four groups according to tumor size. Serum levels of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1), resistin and visfatin were determined by enzyme immunoassay.
Elevated levels of CEACAM1, resistin and visfatin were observed in breast cancer patients when compared with normal control and benign groups. The cutoff values, sensitivities and specificities of these biomarkers were appropriate for the discrimination of breast cancer from controls. Additionally, the serum levels of visfatin increased positively with tumor size and consequently with breast cancer stages.
CEACAM1, resistin and visfatin are valuable in early diagnosis of breast cancer, with visfatin being preferentially used in staging.
乳腺癌是女性中最相关的恶性肿瘤之一。早期诊断和准确分期乳腺癌对于选择适当的治疗策略和获得更好的结果非常重要。
本研究旨在探讨一些非侵入性生物标志物在埃及乳腺癌患者早期诊断和分期中的意义。
本研究共纳入 135 名经临床和病理证实的女性乳腺癌患者和 40 名无关对照以及 40 名良性乳腺肿块患者。恶性乳腺癌组根据肿瘤大小进一步分为四组。采用酶联免疫吸附法测定血清癌胚抗原相关细胞黏附分子-1（CEACAM1）、抵抗素和内脂素水平。
与正常对照组和良性组相比，乳腺癌患者的 CEACAM1、抵抗素和内脂素水平升高。这些生物标志物的截断值、灵敏度和特异性适合于将乳腺癌与对照组区分开来。此外，内脂素血清水平随肿瘤大小增加而升高，随乳腺癌分期增加而升高。
CEACAM1、抵抗素和内脂素在乳腺癌的早期诊断中有价值，内脂素在分期中更有优势。
Zotero 插件
