Institute of Child Development, University of Minnesota-Twin Cities, Minneapolis, MN, USA.
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, USA.
Dev Psychobiol. 2021 Jul;63(5):851-863. doi: 10.1002/dev.22061. Epub 2020 Nov 29.
Early adverse care has long-term impacts on physical and mental health. The influence of rearing conditions on the infant's gut microbiota and its relationship with developmental health has become more evident. The microbiome is essential for normal growth and metabolism, and the signaling from the gut to the brain may underlie individual differences in resilience later in life. Microbial diversity and composition were determined using 16S rRNA gene amplicon sequencing in fecal samples from 17 adolescents adopted internationally from orphanages into the United States and 18 adolescents reared in birth families who had similar educational and income levels. Analyses focused on diversity of the microbial community structure and differences in the abundance of specific bacterial taxa. Blood samples were used to immunophenotype the numbers of several T-cell subsets and cytomegalovirus (CMV) seropositivity. Negative binomial regression analysis revealed several operational taxonomic units that were significantly different based on early rearing conditions and CMV seropositivity. There were significant associations between the relative abundance of certain taxa, the percentages of T-cell subsets in circulation, and CMV seropositivity. These findings demonstrate a possible link between the gut microbiota and associations with immune alterations initiated by early life adversity.
早期不良养育对身心健康有长期影响。养育条件对婴儿肠道微生物群及其与发育健康的关系的影响变得更加明显。微生物组对于正常的生长和代谢至关重要，肠道向大脑发出的信号可能是个体日后适应能力差异的基础。通过对 17 名从孤儿院被国际收养到美国的青少年和 18 名在亲生家庭中成长的青少年的粪便样本进行 16S rRNA 基因扩增子测序，确定了微生物多样性和组成。分析集中在微生物群落结构的多样性和特定细菌分类群丰度的差异上。使用血液样本对几种 T 细胞亚群的免疫表型和巨细胞病毒 (CMV) 血清阳性进行检测。负二项式回归分析显示，根据早期养育条件和 CMV 血清阳性，有几个操作分类单位存在显著差异。某些分类群的相对丰度、循环中 T 细胞亚群的百分比和 CMV 血清阳性之间存在显著关联。这些发现表明肠道微生物群与早期生活逆境引发的免疫改变之间可能存在联系。
