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核心技术专利：CN118964589B侵权必究
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基于黄蓍胶-丝素水凝胶的新型三元磁性纳米生物复合材料用于热疗和生物学性能。

A novel ternary magnetic nanobiocomposite based on tragacanth-silk fibroin hydrogel for hyperthermia and biological properties.

机构信息

Catalysts and Organic Synthesis Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran.

Advanced Chemical Studies Lab, Department of Chemistry, K. N. Toosi University of Technology, Tehran, Iran.

出版信息

Sci Rep. 2024 Apr 8;14(1):8166. doi: 10.1038/s41598-024-58770-9.

DOI:10.1038/s41598-024-58770-9
PMID:38589455
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11002001/
Abstract

This study involves the development of a new nanocomposite material for use in biological applications. The nanocomposite was based on tragacanth hydrogel (TG), which was formed through cross-linking of Ca ions with TG polymer chains. The utilization of TG hydrogel and silk fibroin as natural compounds has enhanced the biocompatibility, biodegradability, adhesion, and cell growth properties of the nanobiocomposite. This advancement makes the nanobiocomposite suitable for various biological applications, including drug delivery, wound healing, and tissue engineering. Additionally, FeO magnetic nanoparticles were synthesized in situ within the nanocomposite to enhance its hyperthermia efficiency. The presence of hydrophilic groups in all components of the nanobiocomposite allowed for good dispersion in water, which is an important factor in increasing the effectiveness of hyperthermia cancer therapy. Hemolysis and 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assays were conducted to evaluate the safety and efficacy of the nanobiocomposite for in-vivo applications. Results showed that even at high concentrations, the nanobiocomposite had minimal hemolytic effects. Finally, the hyperthermia application of the hybrid scaffold was evaluated, with a maximum SAR value of 41.2 W/g measured in the first interval.

摘要

本研究涉及开发一种新的纳米复合材料，用于生物应用。该纳米复合材料基于黄蓍胶水凝胶（TG），通过 TG 聚合物链与 Ca 离子交联形成。将 TG 水凝胶和丝素蛋白用作天然化合物，提高了纳米生物复合材料的生物相容性、可生物降解性、粘附性和细胞生长性能。这一进步使得纳米生物复合材料适用于各种生物应用，包括药物输送、伤口愈合和组织工程。此外，还在纳米复合材料内原位合成了 FeO 磁性纳米粒子，以提高其热疗效率。纳米生物复合材料的所有成分都具有亲水性基团，这有利于其在水中的良好分散，这是提高热疗癌症治疗效果的一个重要因素。进行了溶血和 3-(4,5 二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐试验，以评估纳米生物复合材料用于体内应用的安全性和有效性。结果表明，即使在高浓度下，纳米生物复合材料的溶血作用也很小。最后，评估了杂交支架的热疗应用，在第一个间隔内测量到最大 SAR 值为 41.2 W/g。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/9a0ee2b27e82/41598_2024_58770_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/d29fa72141f5/41598_2024_58770_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/870dba81bd1d/41598_2024_58770_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/ca8dc5e44709/41598_2024_58770_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/c4a1c0878a2a/41598_2024_58770_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/5b6f57e00716/41598_2024_58770_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/6b71393ae0a4/41598_2024_58770_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/12a0139f8a91/41598_2024_58770_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/65887277943e/41598_2024_58770_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/9a0ee2b27e82/41598_2024_58770_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/d29fa72141f5/41598_2024_58770_Sch1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/870dba81bd1d/41598_2024_58770_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/ca8dc5e44709/41598_2024_58770_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/c4a1c0878a2a/41598_2024_58770_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/5b6f57e00716/41598_2024_58770_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/6b71393ae0a4/41598_2024_58770_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/12a0139f8a91/41598_2024_58770_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/65887277943e/41598_2024_58770_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e26/11002001/9a0ee2b27e82/41598_2024_58770_Fig8_HTML.jpg

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引用本文的文献

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Organic-Inorganic Hybridization of Silkworm Cocoon Filaments Using Nano Pastes of Silica-Phosphate-M (M = Cu, Fe, or Al).

Nanomaterials (Basel). 2024-10-23

本文引用的文献

[1]
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Int J Biol Macromol. 2023-9-30

[2]
Magnetized chitosan hydrogel and silk fibroin, reinforced with PVA: a novel nanobiocomposite for biomedical and hyperthermia applications.

RSC Adv. 2023-3-14

[3]
The State of the Art of Natural Polymer Functionalized FeO Magnetic Nanoparticle Composites for Drug Delivery Applications: A Review.

Gels. 2023-2-1

[4]
Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic FeO Nanoparticles for Magnetic Hyperthermia Application: The Effects of Concentration, Frequency, and Magnetic Field.

Nanomaterials (Basel). 2023-1-22

[5]
Fabrication of a magnetic alginate-silk fibroin hydrogel, containing halloysite nanotubes as a novel nanocomposite for biological and hyperthermia applications.

Sci Rep. 2022-9-14

[6]
Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives.

Nanomaterials (Basel). 2022-5-25

[7]
Paramylon hydrogel: A bioactive polysaccharides hydrogel that scavenges ROS and promotes angiogenesis for wound repair.

Carbohydr Polym. 2022-8-1

[8]
Chitosan/Silk Fibroin Materials for Biomedical Applications-A Review.

Polymers (Basel). 2022-3-26

[9]
Combination therapy with radiation and hyperthermia-induced clinical complete response of small cell carcinoma of prostate.

IJU Case Rep. 2022-1-14

[10]
Recent advances in polysaccharide-based self-healing hydrogels for biomedical applications.

Carbohydr Polym. 2022-5-1

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