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聚（ADP-核糖）聚合酶、聚（ADP-核糖）及烟酰胺腺嘌呤二核苷酸代谢及其在癌症中的抑制剂

PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer.

作者信息

Curtin Nicola, Bai Péter

机构信息

Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

出版信息

Cancers (Basel). 2020 Nov 24;12(12):3494. doi: 10.3390/cancers12123494.

DOI:10.3390/cancers12123494
PMID:33255262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7760776/
Abstract

The role of poly(ADP-ribose) polymerase-1 (PARP1) in DNA repair and as a potential target for anticancer therapy has been under investigation for more than 50 years [...].

摘要

聚（ADP - 核糖）聚合酶 -1（PARP1）在DNA修复中的作用以及作为抗癌治疗潜在靶点的研究已经开展了50多年[……]

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PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer.聚（ADP-核糖）聚合酶、聚（ADP-核糖）及烟酰胺腺嘌呤二核苷酸代谢及其在癌症中的抑制剂
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本文引用的文献

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The Nucleolus and PARP1 in Cancer Biology.癌症生物学中的核仁与聚（ADP-核糖）聚合酶1
Cancers (Basel). 2020 Jul 6;12(7):1813. doi: 10.3390/cancers12071813.
2
The Modified Phenanthridine PJ34 Unveils an Exclusive Cell-Death Mechanism in Human Cancer Cells.改良菲啶PJ34揭示了人类癌细胞中一种独特的细胞死亡机制。
Cancers (Basel). 2020 Jun 19;12(6):1628. doi: 10.3390/cancers12061628.
3
Combined PARP Inhibition and Immune Checkpoint Therapy in Solid Tumors.实体瘤中的PARP抑制与免疫检查点联合治疗
Cancers (Basel). 2020 Jun 9;12(6):1502. doi: 10.3390/cancers12061502.
4
Targeting Nuclear NAD Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells.靶向细胞核NAD合成可抑制DNA修复、损害代谢适应并增加U-2OS骨肉瘤细胞的化学敏感性。
Cancers (Basel). 2020 May 7;12(5):1180. doi: 10.3390/cancers12051180.
5
ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms.ATR抑制通过多种机制增强PARP抑制剂在高危神经母细胞瘤细胞系中的细胞毒性。
Cancers (Basel). 2020 Apr 28;12(5):1095. doi: 10.3390/cancers12051095.
6
Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Deficiency.小鼠胚胎干细胞的致瘤性降低及在缺陷状态下增强的抗肿瘤治疗效果
Cancers (Basel). 2020 Apr 24;12(4):1056. doi: 10.3390/cancers12041056.
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Therapeutic Strategies and Biomarkers to Modulate PARP Activity for Targeted Cancer Therapy.调节PARP活性用于靶向癌症治疗的治疗策略和生物标志物
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Exploring the Synergy between PARP and CHK1 Inhibition in Matched Mutant and Corrected Cells.探索PARP与CHK1抑制在匹配的突变细胞和校正细胞中的协同作用。
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