聚（ADP-核糖）聚合酶、聚（ADP-核糖）及烟酰胺腺嘌呤二核苷酸代谢及其在癌症中的抑制剂
PARPs, PAR and NAD Metabolism and Their Inhibitors in Cancer.
作者信息
Curtin Nicola, Bai Péter
机构信息
Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.
出版信息
Cancers (Basel). 2020 Nov 24;12(12):3494. doi: 10.3390/cancers12123494.
Abstract
The role of poly(ADP-ribose) polymerase-1 (PARP1) in DNA repair and as a potential target for anticancer therapy has been under investigation for more than 50 years [...].
摘要
聚（ADP - 核糖）聚合酶 -1（PARP1）在DNA修复中的作用以及作为抗癌治疗潜在靶点的研究已经开展了50多年[……]
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