Gillie Breanne, Kmeid Michael, Asarian Armand, Xiao Philip
Department of Medicine, St George's University School of Medicine, True Blue, Grenada, WI, USA.
Department of Surgery, The Brooklyn Hospital Center, Icahn School of Medicine at Mount Sinai, Brooklyn, NY, USA.
J Surg Case Rep. 2020 Nov 27;2020(11):rjaa483. doi: 10.1093/jscr/rjaa483. eCollection 2020 Nov.
Adenoid cystic carcinoma (ACC) of the breast is a rare malignancy, accounting for 0.1-1% of breast cancers. Histologically breast ACC is similar to ACC's found in salivary tissue and is a triple-negative breast cancer with an uncharacteristically favorable prognosis and low incidence of metastasis. Most cases present as a painful, palpable mass; however, asymptomatic cases found on screening mammograms have also been noted. Core needle biopsy or excisional biopsy is necessary for definitive diagnosis of breast ACC. Immunohistochemistry of these cancers can differentiate breast ACC from masses with similar histology, such as invasive cribriform carcinoma and collagenous spherulosis. There is no well-established treatment guideline for ACC; however, it has been noted that reoccurrence and metastasis are noted more in cases of local resection than mastectomy.
乳腺腺样囊性癌（ACC）是一种罕见的恶性肿瘤，占乳腺癌的0.1%-1%。从组织学上看，乳腺ACC与唾液腺组织中的ACC相似，是一种三阴性乳腺癌，预后异常良好，转移发生率低。大多数病例表现为疼痛、可触及的肿块；然而，也有在乳腺钼靶筛查中发现的无症状病例。对于乳腺ACC的明确诊断，粗针活检或切除活检是必要的。这些癌症的免疫组织化学可以将乳腺ACC与组织学相似的肿块区分开来，如浸润性筛状癌和胶原小球病。目前尚无针对ACC的成熟治疗指南；然而，已经注意到，与乳房切除术相比，局部切除病例的复发和转移更为常见。
