Jandova Tereza, Buendía-Romero Angel, Polanska Hana, Hola Veronika, Rihova Marcela, Vetrovsky Tomas, Courel-Ibáñez Javier, Steffl Michal
Faculty of Physical Education and Sport, Charles University, 16252 Prague, Czech Republic.
Faculty of Sport Sciences, University of Murcia, 30720 Murcia, Spain.
Healthcare (Basel). 2021 Oct 25;9(11):1438. doi: 10.3390/healthcare9111438.
Physical exercise may activate a number of important biochemical processes in the human body. The aim of this systematic review and meta-analysis was to identify the long-term effect of physical activity on irisin blood levels. We searched PubMed, Scopus, and Web of Science for articles addressing the long-term effect of physical exercise on irisin blood levels. Fifty-nine articles were included in the final qualitative and quantitative syntheses. A statistically significant within-group effect of exercise on irisin blood levels was in 33 studies; out of them, the irisin level increased 23× and decreased 10×. The significant positive between-groups effect was found 11×. Furthermore, the meta-analysis indicated that physical exercise had a significant positive effect on irisin blood levels (SMD = 0.39 (95% CI 0.27-0.52)). Nevertheless, considerably high heterogeneity was found in all the analyses. This systematic review and meta-analysis indicate that physical exercise might increase irisin blood levels; however, the results of individual studies were considerably inconsistent, which questions the methodological detection of irisin by ELISA kits.
体育锻炼可能会激活人体中的一些重要生化过程。本系统评价和荟萃分析的目的是确定体育活动对鸢尾素血液水平的长期影响。我们在PubMed、Scopus和科学网中检索了探讨体育锻炼对鸢尾素血液水平长期影响的文章。最终的定性和定量综合分析纳入了59篇文章。33项研究中，锻炼对鸢尾素血液水平的组内效应具有统计学意义；其中，鸢尾素水平升高23次，降低10次。组间显著正效应出现11次。此外，荟萃分析表明体育锻炼对鸢尾素血液水平有显著正效应（标准化均数差=0.39（95%置信区间0.27-0.52））。然而，在所有分析中均发现了相当高的异质性。本系统评价和荟萃分析表明，体育锻炼可能会提高鸢尾素血液水平；然而，个别研究的结果差异很大，这对ELISA试剂盒检测鸢尾素的方法学提出了质疑。
