Wong Russell, Murphy Angela, Lira Monica, Sichmann Mariangela G de O, Kim Alexis R, Saechee Veronica D, Hermanson Kevin D, Hawkins Stacy S
Rejuvenation Medical Group, 5083 Windermere Blvd Unit 101, Edmonton, AB, T6W 0J5, Canada.
Dermalogica, LLC, Carson, CA, USA.
Dermatol Ther (Heidelb). 2023 Dec;13(12):3057-3069. doi: 10.1007/s13555-023-01049-0. Epub 2023 Oct 14.
Microneedling is a cosmetic procedure that leverages the skin's natural ability to heal in order to promote collagen formation and skin rejuvenation. To provide improved results, the technique can be combined with topical formulations. A new formulation of multiple actives, including omega-3 (n-3) polyunsaturated fatty acids (PUFAs), was designed to accelerate the resolution of inflammation and wound healing following micro-injury treatments, while enhancing the visible appearance of procedure results, including erythema, luminosity and skin texture.
In this randomised, controlled, split-face study, we examined 32 healthy female participants aged 30-70 years for 4 weeks following microneedling treatment with a novel multiple-active-ingredient formulation or conventional microneedling protocol with a hyaluronic acid control serum. Changes in skin condition were assessed by blinded clinical photography and expert evaluation. Measurements were collected at baseline, 1 h, 1 day, 7 days and 28 days post treatment.
Significantly greater improvements in expert-assessed erythema, luminosity and skin texture were reported following application of the novel multiple-active-ingredient formulation than the hyaluronic acid control serum. This was confirmed by representative VISIA®-CR imaging.
These data provide new evidence for the role of a novel multiple-active-ingredient formulation for improving skin outcomes up to 28 days following microneedling in adults with healthy skin when compared with a hyaluronic acid serum. The n-3 PUFA content of this formulation may drive accelerated inflammation resolution and wound healing alongside the complementary action of the other active ingredients, leading to the observed improvements in erythema, luminosity and skin texture.
微针疗法是一种美容程序，它利用皮肤的自然愈合能力来促进胶原蛋白生成和皮肤焕新。为了获得更好的效果，该技术可与局部用制剂联合使用。一种包含ω-3（n-3）多不饱和脂肪酸（PUFA）等多种活性成分的新制剂，旨在加速微损伤治疗后的炎症消退和伤口愈合，同时增强治疗效果的可见外观，包括红斑、光泽度和皮肤质地。
在这项随机、对照、半脸研究中，我们对32名年龄在30 - 70岁的健康女性参与者进行了研究，在她们接受微针治疗后的4周内，一组使用新型多活性成分制剂，另一组使用含透明质酸对照血清的传统微针方案。通过盲法临床摄影和专家评估来评估皮肤状况的变化。在治疗前基线、治疗后1小时、1天、7天和28天收集测量数据。
与透明质酸对照血清相比，使用新型多活性成分制剂后，专家评估的红斑、光泽度和皮肤质地有显著更大的改善。代表性的VISIA®-CR成像证实了这一点。
这些数据为一种新型多活性成分制剂在改善健康皮肤成年人微针治疗后长达28天的皮肤效果方面的作用提供了新证据。与透明质酸血清相比，该制剂中的n-3 PUFA含量可能与其他活性成分的互补作用一起，推动炎症更快消退和伤口愈合，从而使红斑、光泽度和皮肤质地得到改善。
