用于韩国产品制造的IDCC 2201的安全性评估。
Safety assessment of IDCC 2201 used for product manufacturing in Korea.
作者信息
Ban O-Hyun, Oh Sangki, Park Chanmi, Bang Won Yeong, Lee Bo Som, Yang Soo-Yeon, Chae Seung A, Jung Young Hoon, Yang Jungwoo
机构信息
Ildong Bioscience Gyeonggi-do South Korea.
School of Food Science and Biotechnology Kyungpook National University Daegu South Korea.
出版信息
Food Sci Nutr. 2020 Oct 2;8(11):6269-6274. doi: 10.1002/fsn3.1925. eCollection 2020 Nov.
Abstract
Safety evaluation of probiotics has become increasingly important for human consumption in food industry. The aims of this study were to assess safety of IDCC 2201 through in vitro and in vivo tests. In results, this strain was found to be negative for hemolytic and β-glucuronidase activity. In addition, IDCC 2201 was susceptible to nine antibiotics suggested by EFSA. In accordance with MIC tests, whole-genome analysis indicated that . IDCC 2201 neither harbors antibiotic resistance nor toxigenic genes. Furthermore, none of the biogenic amines including tyramine and histamine was produced and negligible amounts of D-lactate were produced by . IDCC 2201. Finally, it was confirmed that there was no mortality and toxicity throughout single-dose oral toxicity tests in rats. Therefore, we report that IDCC 2201 is considered to be safe for human consumption as probiotics.
摘要
益生菌的安全性评估对于食品工业中的人类消费而言变得愈发重要。本研究的目的是通过体外和体内试验评估IDCC 2201的安全性。结果发现，该菌株的溶血活性和β-葡萄糖醛酸酶活性均为阴性。此外，IDCC 2201对欧洲食品安全局（EFSA）建议的九种抗生素敏感。根据最低抑菌浓度（MIC）测试，全基因组分析表明，IDCC 2201既不携带抗生素抗性基因也不携带产毒基因。此外，IDCC 2201未产生包括酪胺和组胺在内的任何生物胺，且产生的D-乳酸量可忽略不计。最后，在大鼠单剂量口服毒性试验中证实未出现死亡和毒性情况。因此，我们报告称，IDCC 2201作为益生菌被认为对人类消费是安全的。
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