Kumar Suresh, Yadav Pardeep Kumar, Srinivasan Ramesh, Perumal Nagarajan
National Institute of Biologicals, Noida, UP India.
Central Animal Facility, All India Institute of Medical Science, New Delhi, India.
Virusdisease. 2020 Dec;31(4):453-458. doi: 10.1007/s13337-020-00637-4. Epub 2020 Dec 2.
The researcher community across the globe is on a search for a promising animal model that closely mimics the clinical manifestation of SARS-CoV-2. Though some developments were seen such as serial adaptation in various animal species or the creation of genetically engineered models, a suitable animal model remains elusive. A model that could display the severity of human illness and can be used for the fast-track evaluation of potential drugs as well as for the clinical trials of vaccines is an urgent need of the hour. In the light of huge information generated on SARS-CoV-2 and daily updates received from the research community, we have chosen to review the current status of animal models of SARS-CoV-2 in encompassing the areas of viral replication, transmission, active/passive immunization, clinical disease, and pathology. The review is intended to help the researchers in the selection of appropriate animal models for SARS CoV-2 research in the fight against the current global pandemic.
全球的研究人员都在寻找一种能紧密模拟新冠病毒临床表现的理想动物模型。尽管取得了一些进展，比如在各种动物物种中进行连续传代适应或创建基因工程模型，但合适的动物模型仍然难以找到。当下迫切需要一种能够展现人类疾病严重程度、可用于快速评估潜在药物以及疫苗临床试验的模型。鉴于关于新冠病毒产生的海量信息以及从研究界获得的每日更新，我们选择回顾新冠病毒动物模型在病毒复制、传播、主动/被动免疫、临床疾病和病理学等领域的现状。这篇综述旨在帮助研究人员在抗击当前全球大流行的过程中，为新冠病毒研究选择合适的动物模型。
