Information causality measures have proven to be very effective in uncovering the connectivity patterns of multivariate systems. The non-uniform embedding (NUE) scheme has been developed to address the "curse of dimensionality", since the estimation relies on high-dimensional conditional mutual information (CMI) terms. Although the NUE scheme is a dimension reduction technique, the estimation of high-dimensional CMIs is still required. A possible solution is the utilization of low-dimensional approximation (LA) methods for the computation of CMIs. In this study, we aim to provide useful insights regarding the effectiveness of causality measures that rely on NUE and/or on LA methods. In a comparative study, three causality detection methods are evaluated, namely partial transfer entropy (PTE) defined using uniform embedding, PTE using the NUE scheme (PTENUE), and PTE utilizing both NUE and an LA method (LATE). Results from simulations on well known coupled systems suggest the superiority of PTENUE over the other two measures in identifying the true causal effects, having also the least computational cost. The effectiveness of PTENUE is also demonstrated in a real application, where insights are presented regarding the leading forces in financial data.