Ferraris Sara, Spriano Silvia, Scalia Alessandro Calogero, Cochis Andrea, Rimondini Lia, Cruz-Maya Iriczalli, Guarino Vincenzo, Varesano Alessio, Vineis Claudia
Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy.
Department of Health Sciences, Center for Translational Research on Autoimmune and Allergic Diseases-CAAD, Università del Piemonte Orientale UPO, 28100 Novara, Italy.
Polymers (Basel). 2020 Dec 3;12(12):2896. doi: 10.3390/polym12122896.
Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.
作为一种用于生产随机和取向聚合物纤维的环保且经济的技术，静电纺丝在生物医学领域正越来越受到关注。本综述的目的是概述静电纺丝在生产用于生物医学应用的纤维方面的潜力，重点关注结合生物力学和拓扑刺激的可能性。事实上，聚合物的选择以及纤维最终的表面改性允许选择适当的化学/生物信号传递给细胞。此外，纤维取向、尺寸和拓扑结构的合理设计也能够从空间角度为引导细胞生长提供机会。为此，本综述首先介绍了使用合成聚合物和天然聚合物通过静电纺丝获得随机和取向纤维的潜力。在本文的第二部分深入研究并讨论了可由纤维组成和拓扑结构引导和促进的生物现象。最后，在最后一部分介绍并讨论了科学界为实现静电纺丝纤维及其用于生物医学应用的表面改性而开发的最新策略。
