Lim Hyeon-Ji, Park In-Sun, Jie Eun Yee, Ahn Woo Seok, Kim Sang-Jun, Jeong Seung-Il, Yu Kang-Yeol, Kim Suk Weon, Jung Chan-Hun
Jeonju AgroBio-Materials Institute, Jeonju-si, Jeollabuk-do 54810, Korea.
Biological Resource Center, Korea Research Institute of Bioscience & Biotechnology, Jeongeup-si, Jeollabuk-do 56212, Korea.
Plants (Basel). 2020 Dec 3;9(12):1701. doi: 10.3390/plants9121701.
has been traditionally used to treat dysentery, enteritis, flatulence, and itchiness. However, the existence of anti-inflammatory effects of on -induced skin disease is unknown. In vitro cultures of plant cells and tissues produced under controlled conditions offer a continuous production platform for plant natural products including pigments and anti-inflammatory agents. In this study, we determine the anti-inflammatory activities of an extract of in vitro grown adventitious shoots of on , the etiologic agent of skin inflammation. The extract of showed antioxidant and anti-inflammatory activity in LPS-treated RAW264.7 cells. It also had antibacterial activity and anti-inflammatory effects on -treated HaCaT cells. In addition, these effects were regulated by suppression of the mitogen-activated protein kinase (MAPK) pathways. These results suggesting the potential application of adventitious shoots of grown with an in vitro proliferation system as a medicine for treating -induced inflammatory skin disease.
传统上一直用于治疗痢疾、肠炎、肠胃胀气和瘙痒。然而，其对诱导性皮肤病的抗炎作用尚不清楚。在可控条件下进行的植物细胞和组织的体外培养为包括色素和抗炎剂在内的植物天然产物提供了一个持续生产平台。在本研究中，我们测定了体外培养的不定芽提取物对皮肤炎症病原体的抗炎活性。提取物在脂多糖处理的RAW264.7细胞中表现出抗氧化和抗炎活性。它对处理过的HaCaT细胞也有抗菌活性和抗炎作用。此外，这些作用是通过抑制丝裂原活化蛋白激酶（MAPK）途径来调节的。这些结果表明，利用体外增殖系统培养的不定芽作为治疗诱导性炎症性皮肤病的药物具有潜在应用价值。
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