Zhu Hongkang, Hu Bin, Hua Hanyi, Liu Chang, Cheng Yuliang, Guo Yahui, Yao Weirong, Qian He
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Food Res Int. 2020 Dec;138(Pt B):109819. doi: 10.1016/j.foodres.2020.109819. Epub 2020 Oct 20.
Macamides, the major bioactive compounds of Lepidium meyenii (Walp.) or Maca, are a unique class of non-polar, long chain fatty acid N-benzylamides with fertility-enhancing, neuroprotective, neuro-modulatory, anti-fatigue and anti-osteoporosis effects. However, the relationship between the structures and pharmacological effects of macamides have not been established so far. In addition, little is known regarding their biosynthetic pathways and the mechanisms underlying the biological activities. In this review, we have summarized the methods currently used for the extraction, purification and synthesis of macamides. Their pharmacological effects, clinical prospects and biomedical applications have also been discussed. Current data strongly suggest that macamides are a promising bio-active agent, and further studies are warranted to elucidate their mechanisms of action.
玛卡酰胺是玛咖（Lepidium meyenii (Walp.)）的主要生物活性化合物，是一类独特的非极性长链脂肪酸N-苄基酰胺，具有增强生育能力、神经保护、神经调节、抗疲劳和抗骨质疏松作用。然而，迄今为止，玛卡酰胺的结构与药理作用之间的关系尚未明确。此外，关于它们的生物合成途径以及生物活性的潜在机制也知之甚少。在本综述中，我们总结了目前用于玛卡酰胺提取、纯化和合成的方法。还讨论了它们的药理作用、临床前景和生物医学应用。现有数据有力地表明，玛卡酰胺是一种有前景的生物活性剂，有必要进一步研究以阐明其作用机制。
