Zini Avraham, Mann Jonathan, Mazor Sigal, Vered Yuval
Department of Community Dentistry, Faculty of Dental Medicine, Hebrew University and Hadassah, Faculty of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel.
J Clin Biochem Nutr. 2020 Nov;67(3):297-301. doi: 10.3164/jcbn.20-52. Epub 2020 Jul 31.
The purpose of this study is to assess the long-term efficacy of aged garlic extract to improve periodontitis. Two hundred and one participants were randomly stratified and assigned equally to the regimen group or the control group. At the start, 12 month, and 18 month subjects received dental examination and periodontal evaluation. Probing Pocket Depth and Gingival Recession were examined. For each efficacy parameter, the mean value of examination was calculated and assessed using paired-difference tests. Statistical tests were two-sided using a 5% significance level. The mean value of pocket depth for the aged garlic extract group at 18 month was 1.06 ± 0.49 as compared to the baseline value of 1.89 ± 0.74 (<0.001) and the corresponding value of 1.50 ± 0.46 for the placebo group (<0.001), indicating the beneficial effect of aged garlic extract on periodontitis. According to a Multiple linear regression analysis the only three variables which reached statistical significance as predictors of PPD level were the baseline PPD scores (<0.001), smoking ( = 0.020), and consumption of daily dose of aged garlic extract (<0.001). These results demonstrated that aged garlic extract is an effective supplement for preventing or improving periodontal disease. The well demonstrated benefits of aged garlic extract for the oral disease may also be used as a means to improve general health because of the close relationship between periodontitis and some systemic diseases such as diabetes, hypertension, atherosclerosis, and others.
本研究的目的是评估 aged garlic extract（蒜龄提取物）改善牙周炎的长期疗效。201名参与者被随机分层并平均分配到治疗组或对照组。在开始时、12个月和18个月时，受试者接受牙科检查和牙周评估。检查探诊深度和牙龈退缩情况。对于每个疗效参数，计算检查的平均值并使用配对差异检验进行评估。统计检验采用双侧检验，显著性水平为5%。蒜龄提取物组在18个月时的牙周袋深度平均值为1.06±0.49，而基线值为1.89±0.74（<0.001），安慰剂组的相应值为1.50±0.46（<0.001），表明蒜龄提取物对牙周炎有有益作用。根据多元线性回归分析，作为探诊深度水平预测因子达到统计学显著性的仅有的三个变量是基线探诊深度评分（<0.001）、吸烟（P = 0.020）和每日蒜龄提取物剂量的服用情况（<0.001）。这些结果表明，蒜龄提取物是预防或改善牙周疾病的有效补充剂。由于牙周炎与糖尿病、高血压、动脉粥样硬化等一些全身性疾病之间存在密切关系，蒜龄提取物对口腔疾病已充分证明的益处也可作为改善整体健康的一种手段。
