College of Chinese Medicine Materials, Jilin Agricultural University, Changchun, Jilin Province 130118, PR China; College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province 130118, PR China.
College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province 130118, PR China.
Microb Pathog. 2021 Jan;150:104681. doi: 10.1016/j.micpath.2020.104681. Epub 2020 Dec 6.
Bovine leukemia is a chronic, progressive, contagious tumor disease characterized by malignant lymphoid cell hyperplasia and systemic lymphadenopathy, and is caused by bovine leukemia virus (BLV). The disease affects almost all countries and regions where livestock are raised, and may even be a potential zoonotic disease. Monitoring and early prevention of bovine leukemia is very important. Therefore, we conducted this meta-analysis, the first of its type in the country, to estimate the prevalence of bovine leukemia in 1983-2019 in China. We included a total of 35 publications reported in 1983-2019 from the PubMed, ScienceDirect, Chinese Web of Knowledge (CNKI), VIP Chinese, and Wan Fang databases. In those articles, a total of 34,954 cattle had been tested, of which 4701 were positive for BLV infection. The estimated pooled BLV prevalence was 10.0% (4701/34,954). Subgroup analysis showed that there were significant differences for sampling years, detection methods, and age. BLV prevalence was highest in the following subgroups: sampled before 1985 (38.5%, 437/1134), age 3-5 years (22.5%, 231/1044), and detected by PCR (17.9%, 1228/5100). Regarding geographic factors, there were significant differences in the latitude and elevation subgroups. BLV prevalence was lowest in the subgroups of 20-30° latitude (3.3%, 255/5069) 200-1000 m altitude (2.2%, 560/11,990). We also analyzed other subgroups such as region, variety, breeding method, precipitation, humidity, and temperature, however, the differences were not significant. Our research indicated that the BLV was still prevalent in some of areas in China. We recommend strengthening the testing of cattle aged >1 year and using flexible testing methods such as PCR to control the prevalence of bovine leukemia and to prevent persistent infection.
牛白血病是一种慢性、进行性、传染性肿瘤疾病，其特征为恶性淋巴样细胞增生和全身淋巴结病，由牛白血病病毒（BLV）引起。该疾病几乎影响所有饲养牲畜的国家和地区，甚至可能是一种潜在的人畜共患病。监测和早期预防牛白血病非常重要。因此，我们进行了这项荟萃分析，这是该国首次对牛白血病进行的分析，以估计 1983 年至 2019 年中国牛白血病的流行率。我们共纳入了 1983 年至 2019 年期间发表于 PubMed、ScienceDirect、中国知网（CNKI）、维普中文和万方数据库的 35 篇报告。在这些文章中，共有 34954 头牛接受了检测，其中 4701 头为 BLV 感染阳性。估计的 BLV 总流行率为 10.0%（4701/34954）。亚组分析表明，采样年份、检测方法和年龄存在显著差异。BLV 流行率在以下亚组中最高：采样于 1985 年之前（38.5%，437/1134）、3-5 岁（22.5%，231/1044）和通过 PCR 检测（17.9%，1228/5100）。关于地理因素，在纬度和海拔亚组中存在显著差异。BLV 流行率在 20-30°纬度（3.3%，255/5069）和 200-1000 m 海拔（2.2%，560/11990）的亚组中最低。我们还分析了其他亚组，如地区、品种、饲养方式、降水、湿度和温度，但差异不显著。我们的研究表明，BLV 在我国一些地区仍然流行。我们建议加强对>1 岁牛的检测，并使用 PCR 等灵活的检测方法来控制牛白血病的流行率，防止持续性感染。
