Nowlan Joseph P, Lumsden John S, Russell Spencer
Department of Pathobiology, University of Guelph, Guelph, OT N1G 2W1, Canada.
Center for Innovation in Fish Health, Vancouver Island University, Nanaimo, BC V9R 5S5, Canada.
Pathogens. 2020 Dec 8;9(12):1029. doi: 10.3390/pathogens9121029.
is a genus of gram negative, marine, filamentous bacteria, associated with the presence of disease (tenacibaculosis) at aquaculture sites worldwide; however, infections induced by this genus are poorly characterized. Documents regarding the genus and close relatives were compiled for a literature review, concentrating on ecology, identification, and impacts of potentially pathogenic species, with a focus on Atlantic salmon in Canada. species likely have a cosmopolitan distribution, but local distributions around aquaculture sites are unknown. Eight species of are currently believed to be related to numerous mortality events of fishes and few mortality events in bivalves. The clinical signs in fishes often include epidermal ulcers, atypical behaviors, and mortality. Clinical signs in bivalves often include gross ulcers and discoloration of tissues. The observed disease may differ based on the host, isolate, transmission route, and local environmental conditions. Species-specific identification techniques are limited; high sequence similarities using conventional genes (16S rDNA) indicate that new genes should be investigated. Annotating full genomes, next-generation sequencing, multilocus sequence analysis/typing (MLSA/MLST), matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF), and fatty acid methylesters (FAME) profiles could be further explored for identification purposes. However, each aforementioned technique has disadvantages. Since tenacibaculosis has been observed world-wide in fishes and other eukaryotes, and the disease has substantial economic impacts, continued research is needed.
是革兰氏阴性、海洋丝状细菌的一个属，与世界各地水产养殖场所的疾病（屈挠杆菌病）存在有关；然而，该属引起的感染特征尚不明确。为进行文献综述，收集了有关该属及其近缘种的文献，重点关注潜在致病物种的生态学、鉴定和影响，以加拿大的大西洋鲑鱼为重点。该属物种可能分布于世界各地，但水产养殖场所周围的局部分布情况尚不清楚。目前认为该属的8个物种与鱼类的大量死亡事件以及双壳贝类的少量死亡事件有关。鱼类的临床症状通常包括表皮溃疡、异常行为和死亡。双壳贝类的临床症状通常包括明显的溃疡和组织变色。观察到的疾病可能因宿主、分离株、传播途径和当地环境条件而异。物种特异性鉴定技术有限；使用传统基因（16S rDNA）的高序列相似性表明应研究新的基因。可进一步探索全基因组注释、下一代测序、多位点序列分析/分型（MLSA/MLST）、基质辅助激光解吸/电离飞行时间质谱（MALDI-TOF）和脂肪酸甲酯（FAME）谱以用于鉴定目的。然而，上述每种技术都有缺点。由于在鱼类和其他真核生物中全世界都观察到了屈挠杆菌病，且该疾病具有重大经济影响，因此需要继续开展研究。
