Creative Research Initiative Center for Nanospace-confined Chemical Reactions (NCCR) and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang 37673, Korea.
Center for Soft and Living Matter, Institute for Basic Science (IBS), and ▽Department of Biomedical Engineering, School of Life Sciences and ⊥Department of Chemical Engineering, School of Energy and Chemical EngineeringUlsan National Institute of Science and Technology (UNIST), Ulsan 44919, Korea.
Nano Lett. 2021 Jan 13;21(1):279-287. doi: 10.1021/acs.nanolett.0c03639. Epub 2020 Dec 11.
Next-generation catalysts are urgently needed to tackle the global challenge of antimicrobial resistance. Existing antimicrobials cannot function in the complex and stressful chemical conditions found in biofilms, and as a result, they are unable to infiltrate, diffuse into, and eradicate the biofilm and its associated matrix. Here, we introduce mixed-FeCo-oxide-based surface-textured nanostructures (MTex) as highly efficient magneto-catalytic platforms. These systems can produce defensive ROS over a broad pH range and can effectively diffuse into the biofilm and kill the embedded bacteria. Because the nanostructures are magnetic, biofilm debris can be scraped out of the microchannels. The key antifouling efficacy of MTex originates from the unique surface topography that resembles that of a ploughed field. These are captured as stable textured intermediates during the oxidative annealing and solid-state conversion of β-FeOOH nanocrystals. These nanoscale surfaces will advance progress toward developing a broad array of new enzyme-like properties at the nanobio interface.
为应对全球抗菌药物耐药性挑战，急需开发下一代催化剂。现有的抗菌药物在生物膜中存在的复杂和紧张的化学条件下无法发挥作用，因此它们无法渗透、扩散到生物膜及其相关基质中，并将其消灭。在这里，我们引入基于混合 FeCo 氧化物的表面纹理纳米结构（MTex）作为高效的磁催化平台。这些系统可以在较宽的 pH 范围内产生防御性 ROS，并能有效地扩散到生物膜中杀死嵌入的细菌。由于纳米结构是磁性的，生物膜碎片可以从微通道中刮除。MTex 的关键抗污效果源于其独特的表面形貌，类似于耕过的田地。这些形貌在β-FeOOH 纳米晶的氧化退火和固态转化过程中作为稳定的纹理中间相被捕获。这些纳米级表面将推动在纳米生物界面上开发广泛的新酶样特性的进展。
