2014 年至 2017 年德国禽源临床和非临床大肠杆菌的表型抗菌药物耐药性数据。
Phenotypical antimicrobial resistance data of clinical and non-clinical Escherichia coli from poultry in Germany between 2014 and 2017.
机构信息
Department Biological Safety, German Federal Institute for Risk Assessment, Berlin, Germany.
Department Method Standardisation, Reference Laboratories, Resistance to Antibiotics, Berlin, Germany.
出版信息
PLoS One. 2020 Dec 11;15(12):e0243772. doi: 10.1371/journal.pone.0243772. eCollection 2020.
Antimicrobial resistance (AMR) is a global threat in humans and animals, and antimicrobial usage (AMU) has been identified as a main trigger of AMR. The purpose of this work was to compare data on AMR in clinical and non-clinical isolates of Escherichia coli in German broilers and turkeys between 2014 and 2017. Furthermore, we investigated AMR changes over time and the association of changes in AMU with changes in AMR. Data on clinical and non-clinical isolates together with data on therapy frequency of broilers and turkeys were collected from German monitoring systems. Logistic regression analyses were performed to assess the association between the explanatory factors (AMU, year and isolate type) and the dependent variable (AMR). In broilers, the analysis showed lower resistance proportions of clinical isolates of E. coli to ampicillin and colistin (ampicillin: Odds ratio (OR) and 95% confidence interval (CI) = 0.44 (0.3-0.64), p<0.001; colistin: OR and 95% CI = 0.75 (0.73-0.76), p<0.001) but higher proportions for cefotaxime (OR and 95% CI = 4.58 (1.56-15.1), p = 0.007). Resistance to ampicillin, gentamicin and tetracycline was less frequent in clinical isolates in turkeys (ampicillin: OR and 95% CI = 0.4 (0.29-0.53), p<0.001; gentamicin: OR and 95% CI = 0.5 (0.26-0.94), p = 0.035; tetracycline: OR and 95% CI = 0.4 (0.29-0.55), p<0.001). The analysis found decreasing associations of AMU with resistance to tetracycline in turkeys and to colistin in broilers. Year was associated with a decrease in resistance to colistin in broilers and to tetracycline in turkeys. Differences in resistance found in this study between clinical and non-clinical isolates might play an important role in resistance prevalence. This study indicated that further data analyses over longer time intervals are required to clarify the differences found between clinical and non-clinical isolates and to assess the long-term effects of changes in AMU on the prevalence of AMR.
抗微生物药物耐药性（AMR）是人类和动物面临的全球性威胁，抗微生物药物使用（AMU）已被确定为 AMR 的主要触发因素。本研究的目的是比较 2014 年至 2017 年期间德国肉鸡和火鸡临床和非临床分离的大肠杆菌中 AMR 数据。此外，我们还研究了 AMR 的时间变化以及 AMU 变化与 AMR 变化之间的关系。从德国监测系统收集了临床和非临床分离物的数据以及肉鸡和火鸡的治疗频率数据。使用逻辑回归分析评估了解释因素（AMU、年份和分离物类型）与因变量（AMR）之间的关联。在肉鸡中，分析显示临床分离的大肠杆菌对氨苄西林和黏菌素的耐药比例较低（氨苄西林：比值比（OR）和 95%置信区间（CI）=0.44（0.3-0.64），p<0.001；黏菌素：OR 和 95%CI =0.75（0.73-0.76），p<0.001），但头孢噻肟的耐药比例较高（OR 和 95%CI =4.58（1.56-15.1），p=0.007）。火鸡临床分离物对氨苄西林、庆大霉素和四环素的耐药性较低（氨苄西林：OR 和 95%CI =0.4（0.29-0.53），p<0.001；庆大霉素：OR 和 95%CI =0.5（0.26-0.94），p=0.035；四环素：OR 和 95%CI =0.4（0.29-0.55），p<0.001）。分析发现，AMU 与火鸡中四环素和肉鸡中黏菌素的耐药性呈下降趋势。年份与肉鸡中黏菌素和火鸡中四环素的耐药性下降有关。本研究在临床和非临床分离物之间发现的耐药性差异可能在耐药性流行中发挥重要作用。本研究表明，需要进行更长时间间隔的进一步数据分析，以阐明临床和非临床分离物之间的差异，并评估 AMU 变化对 AMR 流行率的长期影响。
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