Sabit Hussein, Cevik Emre, Tombuloglu Huseyin, Abdel-Ghany Shaimaa, Tombuloglu Guzin, Esteller Manel
Department of Genetics, Institute for Medical Research and Consultations, Imam Abdulrahman Bin Faisal University, P. O. Box: 1982, 31441, Dammam, Saudi Arabia.
Department of Genetics, Institute for Medical Research and Consultations, Imam Abdulrahman Bin Faisal University, P. O. Box: 1982, 31441, Dammam, Saudi Arabia.
Crit Rev Oncol Hematol. 2021 Jan;157:103196. doi: 10.1016/j.critrevonc.2020.103196. Epub 2020 Dec 9.
The objective of this review is to elucidate the role of miRNAs in triple negative breast cancer (TNBC). To achieve our goal, we searched databases such as PubMed, ScienceDirect, Springer, Web of Science and Scopus. We retrieved up to 1233 articles, based a rigorous selection criterion, only 197 articles were extensively reviewed. We selected articles only addressing TNBC, but not other types of breast cancer, with the employed approach being miRNA analysis and/or profiling. Our extensive review resulted in grouping of miRNAs into categories in which specific members of miRNAs have roles in specific mechanism in TNBC i.e., carcinogenesis, invasion, metastasis, apoptosis, diagnosis, prognosis, and treatment. TNBC is an aggressive subtype of breast cancer; therefore, different approaches for accurate diagnosis, prognosis and treatment are needed. In this review we summarize the up-to-date miRNA profiling, prognostic, and therapeutic findings that add to the route of controlling TNBC.
本综述的目的是阐明微小RNA（miRNA）在三阴性乳腺癌（TNBC）中的作用。为实现这一目标，我们检索了诸如PubMed、ScienceDirect、Springer、Web of Science和Scopus等数据库。我们共检索到1233篇文章，基于严格的筛选标准，仅对其中197篇文章进行了全面综述。我们仅选择了那些专门针对TNBC而非其他类型乳腺癌的文章，所采用的方法为miRNA分析和/或谱分析。我们的全面综述结果将miRNA分为不同类别，其中特定的miRNA成员在TNBC的特定机制中发挥作用，即致癌作用、侵袭、转移、凋亡、诊断、预后和治疗。TNBC是一种侵袭性乳腺癌亚型；因此，需要采用不同的方法进行准确的诊断、预后评估和治疗。在本综述中，我们总结了最新的miRNA谱分析、预后及治疗研究结果，这些结果为控制TNBC的途径增添了内容。
