Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA.
Trends Cancer. 2021 Mar;7(3):185-187. doi: 10.1016/j.trecan.2020.11.006. Epub 2020 Dec 9.
Fusobacterium nucleatum is an oral bacterium associated with colorectal cancer (CRC) proliferation, chemoresistance, inflammation, metastasis, and now DNA damage. While controlling F. nucleatum through antibiotics could reduce cancer severity, this article proposes additional strategies to block Fusobacterium-host interactions, as well as treatment of activated host immune and oncogenic signaling pathways in CRC.
具核梭杆菌是一种与结直肠癌（CRC）增殖、化学抗性、炎症、转移有关的口腔细菌，现在还与 DNA 损伤有关。虽然通过抗生素控制具核梭杆菌可以降低癌症的严重程度，但本文还提出了其他策略来阻断梭状芽孢杆菌与宿主的相互作用，以及治疗 CRC 中被激活的宿主免疫和致癌信号通路。
