• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于外科手术的光固化聚合物共混物

Photocurable Polymeric Blends for Surgical Application.

作者信息

Cernadas Teresa, Santos Marta, Miguel Sónia P, Correia Ilídio J, Alves Patrícia, Ferreira Paula

机构信息

CIEPQPF, Department of Chemical Engineering, University of Coimbra, P-3030 790 Coimbra, Portugal.

CICS-UBI, Health Sciences Research Center, University of Beira Interior, P-6200 506 Covilhã, Portugal.

出版信息

Materials (Basel). 2020 Dec 12;13(24):5681. doi: 10.3390/ma13245681.

DOI:10.3390/ma13245681
PMID:33322771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7763592/
Abstract

The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring and growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.

摘要

研究了由乳酸和聚己内酯（PCL）的低聚物合成的可光交联生物粘合剂的制备，这两种低聚物均用丙烯酸2-异氰基乙酯（AOI）进行了官能化。通过核磁共振氢谱对获得的LA-AOI（mL A）和PCL-AOI（mCL）改性大分子单体进行了化学表征，并用于分别配制质量比为1:1、1:2和2:1的聚合物共混物。随后，考虑两种紫外线照射时间：30秒和120秒，对制备的共混物进行交联。制备完成后，评估了生物粘合剂的热性能和机械性能，测定了其流变学、凝胶含量、水解降解和动态接触角。此外，评估了生物粘合剂与人皮肤成纤维细胞接触时的细胞毒性，同时通过监测细菌生长研究了其抗菌效果。总体而言，获得了柔韧性好且坚韧的薄膜，呈现出有望用作手术生物粘合剂的特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/f3e82a9119e9/materials-13-05681-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/aa9cc0624da5/materials-13-05681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/66236e16a7c6/materials-13-05681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/9afbab06552a/materials-13-05681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/a9cbfc92426f/materials-13-05681-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/c5d5cb4d00d3/materials-13-05681-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/2b8ea210a048/materials-13-05681-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/39e5cc92ecbf/materials-13-05681-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/95ba32427d87/materials-13-05681-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/27121d9f877b/materials-13-05681-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/f3e82a9119e9/materials-13-05681-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/aa9cc0624da5/materials-13-05681-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/66236e16a7c6/materials-13-05681-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/9afbab06552a/materials-13-05681-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/a9cbfc92426f/materials-13-05681-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/c5d5cb4d00d3/materials-13-05681-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/2b8ea210a048/materials-13-05681-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/39e5cc92ecbf/materials-13-05681-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/95ba32427d87/materials-13-05681-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/27121d9f877b/materials-13-05681-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faeb/7763592/f3e82a9119e9/materials-13-05681-g010.jpg

相似文献

1
Photocurable Polymeric Blends for Surgical Application.用于外科手术的光固化聚合物共混物
Materials (Basel). 2020 Dec 12;13(24):5681. doi: 10.3390/ma13245681.
2
Photocurable bioadhesive based on lactic acid.基于乳酸的光固化生物粘合剂。
Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:601-9. doi: 10.1016/j.msec.2015.09.009. Epub 2015 Sep 7.
3
Evaluation of nanofibrous scaffolds obtained from blends of chitosan, gelatin and polycaprolactone for skin tissue engineering.壳聚糖、明胶和聚己内酯共混物制备的纳米纤维支架在皮肤组织工程中的评价。
Int J Biol Macromol. 2017 Sep;102:1174-1185. doi: 10.1016/j.ijbiomac.2017.05.004. Epub 2017 May 6.
4
Preparation and characterization of biodegradable PLA polymeric blends.可生物降解聚乳酸聚合物共混物的制备与表征
Biomaterials. 2003 Mar;24(7):1167-73. doi: 10.1016/s0142-9612(02)00466-0.
5
Microstructure and mechanical properties of biodegradable poly (D/L) lactic acid/polycaprolactone blends processed from the solvent-evaporation technique.通过溶剂蒸发技术制备的可生物降解聚（D/L）乳酸/聚己内酯共混物的微观结构与力学性能
Mater Sci Eng C Mater Biol Appl. 2017 Feb 1;71:807-819. doi: 10.1016/j.msec.2016.10.070. Epub 2016 Oct 26.
6
Poly(ε-Caprolactone)/Poly(Lactic Acid) Blends Compatibilized by Peroxide Initiators: Comparison of Two Strategies.过氧化物引发剂增容的聚（ε-己内酯）/聚乳酸共混物：两种策略的比较
Polymers (Basel). 2020 Jan 16;12(1):228. doi: 10.3390/polym12010228.
7
Poly(epsilon-caprolactone) and poly(epsilon-caprolactone)-polyvinylpyrrolidone-iodine blends as ureteral biomaterials: characterisation of mechanical and surface properties, degradation and resistance to encrustation in vitro.聚（ε-己内酯）及聚（ε-己内酯）-聚乙烯吡咯烷酮-碘共混物作为输尿管生物材料：力学性能和表面性能的表征、体外降解及抗结垢性能
Biomaterials. 2002 Dec;23(23):4449-58. doi: 10.1016/s0142-9612(02)00158-8.
8
Fibro-porous poliglecaprone/polycaprolactone conduits: synergistic effect of composition and degradation on mechanical properties.纤维多孔聚乙交酯/聚己内酯导管：组成与降解对力学性能的协同作用
Polym Int. 2015 Apr;64(4):547-555. doi: 10.1002/pi.4834.
9
Structuring of composite hydrogel bioadhesives and its effect on properties and bonding mechanism.复合水凝胶生物粘合剂的结构及其对性能和粘结机制的影响。
Acta Biomater. 2017 Mar 15;51:125-137. doi: 10.1016/j.actbio.2017.01.047. Epub 2017 Jan 18.
10
Microbial degradation, cytotoxicity and antibacterial activity of polyurethanes based on modified castor oil and polycaprolactone.基于改性蓖麻油和聚己内酯的聚氨酯的微生物降解、细胞毒性及抗菌活性
J Biomater Sci Polym Ed. 2016 Dec;27(18):1860-1879. doi: 10.1080/09205063.2016.1239948. Epub 2016 Oct 11.

引用本文的文献

1
3D bioprinting and photocrosslinking: emerging strategies & future perspectives.3D 生物打印与光交联：新兴策略与未来展望。
Biomater Adv. 2022 Mar;134:112576. doi: 10.1016/j.msec.2021.112576. Epub 2021 Nov 29.

本文引用的文献

1
Development of a biodegradable polycaprolactone film incorporated with an antimicrobial agent via an extrusion process.通过挤出工艺制备一种掺入抗菌剂的可生物降解聚己内酯薄膜。
Sci Rep. 2019 Dec 27;9(1):20236. doi: 10.1038/s41598-019-56757-5.
2
Production and characterization of a novel asymmetric 3D printed construct aimed for skin tissue regeneration.用于皮肤组织再生的新型不对称 3D 打印构建体的制作和特性研究。
Colloids Surf B Biointerfaces. 2019 Sep 1;181:994-1003. doi: 10.1016/j.colsurfb.2019.06.063. Epub 2019 Jun 28.
3
Polylactic acid: synthesis and biomedical applications.
聚乳酸：合成与生物医学应用。
J Appl Microbiol. 2019 Dec;127(6):1612-1626. doi: 10.1111/jam.14290. Epub 2019 Jun 17.
4
Photocrosslinkable Nanofibrous Asymmetric Membrane Designed for Wound Dressing.用于伤口敷料的可光交联纳米纤维不对称膜
Polymers (Basel). 2019 Apr 10;11(4):653. doi: 10.3390/polym11040653.
5
Electrospun Polycaprolactone/Aloe Vera_Chitosan Nanofibrous Asymmetric Membranes Aimed for Wound Healing Applications.用于伤口愈合应用的静电纺聚己内酯/芦荟壳聚糖纳米纤维不对称膜
Polymers (Basel). 2017 May 21;9(5):183. doi: 10.3390/polym9050183.
6
Production and characterization of electrospun silk fibroin based asymmetric membranes for wound dressing applications.静电纺丝丝素基不对称膜的制备及性能表征及其在创伤敷料中的应用。
Int J Biol Macromol. 2019 Jan;121:524-535. doi: 10.1016/j.ijbiomac.2018.10.041. Epub 2018 Oct 11.
7
Synthesis and Characterization of Polycaprolactone-Based Polyurethanes for the Fabrication of Elastic Guided Bone Regeneration Membrane.基于聚己内酯的聚氨酯的合成与表征及其作为弹性引导骨再生膜的制备。
Biomed Res Int. 2018 May 15;2018:3240571. doi: 10.1155/2018/3240571. eCollection 2018.
8
Recent advances on antimicrobial wound dressing: A review.抗菌创伤敷料的最新进展：综述。
Eur J Pharm Biopharm. 2018 Jun;127:130-141. doi: 10.1016/j.ejpb.2018.02.022. Epub 2018 Feb 17.
9
Blends and Nanocomposite Biomaterials for Articular Cartilage Tissue Engineering.用于关节软骨组织工程的共混物和纳米复合生物材料。
Materials (Basel). 2014 Jul 22;7(7):5327-5355. doi: 10.3390/ma7075327.
10
Production and characterization of polycaprolactone- hyaluronic acid/chitosan- zein electrospun bilayer nanofibrous membrane for tissue regeneration.用于组织再生的聚己内酯-透明质酸/壳聚糖-玉米醇溶蛋白电纺双层纳米纤维膜的制备与表征。
Int J Biol Macromol. 2016 Dec;93(Pt A):1100-1110. doi: 10.1016/j.ijbiomac.2016.09.080. Epub 2016 Sep 22.