From the Department of Neurology, National Center Hospital.
Clin Nucl Med. 2021 Mar 1;46(3):243-245. doi: 10.1097/RLU.0000000000003456.
Amyotrophic lateral sclerosis (ALS) involves both upper motor neurons (UMNs) and lower motor neurons. The detection of UMN involvement, a core component of ALS criteria, is primarily dependent on neurological examination because of a lack of definitive biomarkers. We present the 18F-THK5351 PET images of a 76-year-old man diagnosed with ALS comorbid with Alzheimer disease, demonstrating marked accumulation of 18F-THK5351 in the bilateral precentral gyri. Because 18F-THK5351 binds to monoamine oxidase B highly expressed in astrocytes, where the neurodegenerative process is ongoing, our case highlights that 18F-THK5351 tracer should be a useful marker for detecting UMN neurodegeneration in ALS.
肌萎缩侧索硬化症（ALS）涉及上运动神经元（UMNs）和下运动神经元。由于缺乏明确的生物标志物，UMN 受累的检测，即 ALS 标准的核心组成部分，主要依赖于神经学检查。我们展示了一位 76 岁男性的 18F-THK5351 PET 图像，该男性患有 ALS 合并阿尔茨海默病，双侧中央前回显示出 18F-THK5351 的明显积聚。因为 18F-THK5351 与高度表达于神经退行性过程中星形胶质细胞的单胺氧化酶 B 结合，所以我们的病例突出表明，18F-THK5351 示踪剂应该是用于检测 ALS 中 UMN 神经退行性变的有用标志物。
